Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105786
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Food Science and Nutrition | - |
dc.contributor | Research Institute for Future Food | - |
dc.creator | Wu, H | - |
dc.creator | Zhang, W | - |
dc.creator | Huang, M | - |
dc.creator | Lin, X | - |
dc.creator | Chiou, J | - |
dc.date.accessioned | 2024-04-23T04:31:17Z | - |
dc.date.available | 2024-04-23T04:31:17Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105786 | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Wu H, Zhang W, Huang M, Lin X, Chiou J. Prolonged High-Fat Diet Consumption throughout Adulthood in Mice Induced Neurobehavioral Deterioration via Gut-Brain Axis. Nutrients. 2023; 15(2):392 is available at https://doi.org/10.3390/nu15020392. | en_US |
dc.subject | Gut microbiota | en_US |
dc.subject | Gut-brain axis | en_US |
dc.subject | HFD | en_US |
dc.subject | Neurobehaviors | en_US |
dc.title | Prolonged high-fat diet consumption throughout adulthood in mice induced neurobehavioral deterioration via gut-brain axis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 2 | - |
dc.identifier.doi | 10.3390/nu15020392 | - |
dcterms.abstract | Neuropsychiatric disorders have been one of the worldwide health problems contributing to profound social and economic consequences. It is reported that consumption of an excessive high-fat diet (HFD) in middle age could induce cognitive and emotional dysfunctions, whereas the mechanisms of the effects of long-term HFD intake on brain disorders have not been fully investigated. We propose a hypothesis that prolonged HFD intake throughout adulthood could lead to neurobehavioral deterioration via gut-brain axis. In this study, the adult C57BL/6J mice consuming long-term HFD (24 weeks) exhibited more anxiety-like, depression-like, and disruptive social behaviors and poorer performance in learning and memory than control mice fed with a normal diet (ND). In addition, the homeostasis of gut microbiota was impaired by long-term HFD consumption. Changes in some flora, such as Prevotellaceae_NK3B31_group and Ruminococcus, within the gut communities, were correlated to neurobehavioral alterations. Furthermore, the gut permeability was increased after prolonged HFD intake due to the decreased thickness of the mucus layer and reduced expression of tight junction proteins in the colon. The mRNA levels of genes related to synaptic-plasticity, neuronal development, microglia maturation, and activation in the hippocampus and prefrontal cortex of HFD-fed mice were lower than those in mice fed with ND. Interestingly, the transcripts of genes related to tight junction proteins, ZO-1 and Occludin involved in blood-brain-barrier (BBB), were decreased in both hippocampus and prefrontal cortex after long-term HFD consumption. Those results indicated that chronic consumption of HFD in mice resulted in gut microbiota dysbiosis, which induced decreased expression of mucus and tight junction proteins in the colon, in turn leading to local and systemic inflammation. Those changes could further contribute to the impairment of brain functions and neurobehavioral alterations, including mood, sociability, learning and memory. In short, long-term HFD intake throughout adulthood could induce behavioral phenotypes related to neuropsychiatric disorders via gut-brain axis. The observations of this study provide potential intervention strategies to reduce the risk of HFD via targeting the gut or manipulating gut microbiota. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Nutrients, Jan. 2023, v. 15, no. 2, 392 | - |
dcterms.isPartOf | Nutrients | - |
dcterms.issued | 2023-01 | - |
dc.identifier.scopus | 2-s2.0-85146782654 | - |
dc.identifier.pmid | 36678262 | - |
dc.identifier.eissn | 2072-6643 | - |
dc.identifier.artn | 392 | - |
dc.description.validate | 202404 bcch | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Research Institute of Future Food | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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nutrients-15-00392.pdf | 5.07 MB | Adobe PDF | View/Open |
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