Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105413
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | - |
dc.creator | Krishnamurthy, K | - |
dc.creator | Chan, MMY | - |
dc.creator | Han, YMY | - |
dc.date.accessioned | 2024-04-12T06:52:18Z | - |
dc.date.available | 2024-04-12T06:52:18Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105413 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | © The Author(s) 2022 | en_US |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.rights | The following publication Krishnamurthy, K., Chan, M.M.Y. & Han, Y.M.Y. Neural substrates underlying effortful control deficit in autism spectrum disorder: a meta-analysis of fMRI studies. Sci Rep 12, 20603 (2022) is available at https://doi.org/10.1038/s41598-022-25051-2. | en_US |
dc.title | Neural substrates underlying effortful control deficit in autism spectrum disorder : a meta-analysis of fMRI studies | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 12 | - |
dc.identifier.doi | 10.1038/s41598-022-25051-2 | - |
dcterms.abstract | Effortful control comprises attentional control, inhibitory control, and cognitive flexibility subprocesses. Effortful control is impaired in individuals with autism spectrum disorder, yet its neural underpinnings remain elusive. By conducting a coordinate-based meta-analysis, this study compared the brain activation patterns between autism and typically developing individuals and examined the effect of age on brain activation in each effortful control subprocesses. Meta-analytic results from 22 studies revealed that, individuals with autism showed hypoactivation in the default mode network for tasks tapping inhibitory control functioning (threshold-free cluster enhancement p < 0.001). When these individuals perform tasks tapping attentional control and cognitive flexibility, they exhibited aberrant activation in various brain networks including default mode network, dorsal attention, frontoparietal, visual and somatomotor networks (uncorrected ps < 0.005). Meta-regression analyses revealed that brain regions within the default mode network showed a significant decreasing trend in activation with increasing age (uncorrected p < 0.05). In summary, individuals with autism showed aberrant activation patterns across multiple brain functional networks during all cognitive tasks supporting effortful control, with some regions showing a decrease in activation with increasing age. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Scientific reports, 2022, v. 12, 20603 | - |
dcterms.isPartOf | Scientific reports | - |
dcterms.issued | 2022 | - |
dc.identifier.scopus | 2-s2.0-85142917873 | - |
dc.identifier.pmid | 36446840 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.artn | 20603 | - |
dc.description.validate | 202403 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | others | en_US |
dc.description.fundingText | Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41598-022-25051-2.pdf | 1.98 MB | Adobe PDF | View/Open |
Page views
10
Citations as of Jul 7, 2024
Downloads
2
Citations as of Jul 7, 2024
SCOPUSTM
Citations
2
Citations as of Jul 4, 2024
WEB OF SCIENCETM
Citations
1
Citations as of Jul 4, 2024
![](/image/google_scholar.jpg)
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.