Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105405
DC Field | Value | Language |
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dc.contributor | Department of Applied Physics | - |
dc.creator | Liang, M | - |
dc.creator | Li, F | - |
dc.creator | Wang, Y | - |
dc.creator | Chen, H | - |
dc.creator | Tian, J | - |
dc.creator | Zhao, Z | - |
dc.creator | Schneider, KH | - |
dc.creator | Li, G | - |
dc.date.accessioned | 2024-04-12T06:52:16Z | - |
dc.date.available | 2024-04-12T06:52:16Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105405 | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Liang M, Li F, Wang Y, Chen H, Tian J, Zhao Z, Schneider KH, Li G. Woven Vascular Stent-Grafts with Surface Modification of Silk Fibroin-Based Paclitaxel/Metformin Microspheres. Bioengineering. 2023; 10(4):399 is available at https://doi.org/10.3390/bioengineering10040399. | en_US |
dc.subject | Drug release | en_US |
dc.subject | Metformin | en_US |
dc.subject | Paclitaxel | en_US |
dc.subject | Silk fibroin | en_US |
dc.subject | Stent-graft | en_US |
dc.title | Woven vascular stent-grafts with surface modification of silk fibroin-based paclitaxel/metformin microspheres | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 4 | - |
dc.identifier.doi | 10.3390/bioengineering10040399 | - |
dcterms.abstract | In-stent restenosis caused by tumor ingrowth increases the risk of secondary surgery for patients with abdominal aortic aneurysms (AAA) because conventional vascular stent grafts suffer from mechanical fatigue, thrombosis, and endothelial hyperplasia. For that, we report a woven vascular stent-graft with robust mechanical properties, biocompatibility, and drug delivery functions to inhibit thrombosis and the growth of AAA. Paclitaxel (PTX)/metformin (MET)-loaded silk fibroin (SF) microspheres were self-assembly synthesized by emulsification-precipitation technology and layer-by-layer coated on the surface of a woven stent via electrostatic bonding. The woven vascular stent-graft before and after coating drug-loaded membranes were characterized and analyzed systematically. The results show that small-sized drug-loaded microspheres increased the specific surface area and promoted the dissolution/release of drugs. The stent-grafts with drug-loaded membranes exhibited a slow drug-release profile more for than 70 h and low water permeability at 158.33 ± 17.56 mL/cm2·min. The combination of PTX and MET inhibited the growth of human umbilical vein endothelial cells. Therefore, it was possible to generate dual-drug-loaded woven vascular stent-grafts to achieve the more effective treatment of AAA. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Bioengineering, Apr. 2023, v. 10, no. 4, 399 | - |
dcterms.isPartOf | Bioengineering | - |
dcterms.issued | 2023-04 | - |
dc.identifier.scopus | 2-s2.0-85154543991 | - |
dc.identifier.eissn | 2306-5354 | - |
dc.identifier.artn | 399 | - |
dc.description.validate | 202403 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | National Key R&D Program of China; Science and Technology Partnership Program, Ministry of Science and Technology of China; Jiangsu Provincial Department of Science and Technology; China National Textile and Apparel Council; Jiangsu Advanced Textile Engineering Technology Center | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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bioengineering-10-00399.pdf | 5.07 MB | Adobe PDF | View/Open |
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