Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105350
DC Field | Value | Language |
---|---|---|
dc.contributor | Research Institute for Smart Ageing | - |
dc.contributor | Department of Biomedical Engineering | - |
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Ho, LM | - |
dc.creator | Lam, SK | - |
dc.creator | Zhang, J | - |
dc.creator | Chiang, CL | - |
dc.creator | Chan, ACY | - |
dc.creator | Cai, J | - |
dc.date.accessioned | 2024-04-12T06:51:52Z | - |
dc.date.available | 2024-04-12T06:51:52Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105350 | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Ho L-M, Lam S-K, Zhang J, Chiang C-L, Chan AC-Y, Cai J. Association of Multi-Phasic MR-Based Radiomic and Dosimetric Features with Treatment Response in Unresectable Hepatocellular Carcinoma Patients following Novel Sequential TACE-SBRT-Immunotherapy. Cancers. 2023; 15(4):1105 is available at https://doi.org/10.3390/cancers15041105. | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Immunotherapy | en_US |
dc.subject | Magnetic resonance imaging | en_US |
dc.subject | Radiomics | en_US |
dc.subject | Stereotactic body radiotherapy | en_US |
dc.subject | Trans-arterial chemoembolization | en_US |
dc.title | Association of multi-phasic MR-based radiomic and dosimetric features with treatment response in unresectable hepatocellular carcinoma patients following novel sequential TACE-SBRT-immunotherapy | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 4 | - |
dc.identifier.doi | 10.3390/cancers15041105 | - |
dcterms.abstract | This study aims to investigate the association of pre-treatment multi-phasic MR-based radiomics and dosimetric features with treatment response to a novel sequential trans-arterial chemoembolization (TACE) plus stereotactic body radiotherapy (SBRT) plus immunotherapy regimen in unresectable Hepatocellular Carcinoma (HCC) sub-population. Twenty-six patients with unresectable HCC were retrospectively analyzed. Radiomic features were extracted from 42 lesions on arterial phase (AP) and portal-venous phase (PVP) MR images. Delta-phase (DeltaP) radiomic features were calculated as AP-to-PVP ratio. Dosimetric data of the tumor was extracted from dose-volume-histograms. A two-sided independent Mann–Whitney U test was used to assess the clinical association of each feature, and the classification performance of each significant independent feature was assessed using logistic regression. For the 3-month timepoint, four DeltaP-derived radiomics that characterize the temporal change in intratumoral randomness and uniformity were the only contributors to the treatment response association (p-value = 0.038–0.063, AUC = 0.690–0.766). For the 6-month timepoint, DeltaP-derived radiomic features (n = 4) maintained strong clinical associations with the treatment response (p-value = 0.047–0.070, AUC = 0.699–0.788), additional AP-derived radiomic features (n = 4) that reflect baseline tumoral arterial-enhanced signal pattern and tumor morphology (n = 1) that denotes initial tumor burden were shown to have strong associations with treatment response (p-value = 0.028–0.074, AUC = 0.719–0.773). This pilot study successfully demonstrated associations of pre-treatment multi-phasic MR-based radiomics with tumor response to the novel treatment regimen. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Cancers, Feb. 2023, v. 15, no. 4, 1105 | - |
dcterms.isPartOf | Cancers | - |
dcterms.issued | 2023-02 | - |
dc.identifier.scopus | 2-s2.0-85149025348 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.artn | 1105 | - |
dc.description.validate | 202403 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Shenzhen-Hong Kong-Macau S and T Program (Category C); Shenzhen Science and Technology Innovation Committee, Hong Kong Polytechnic University | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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cancers-15-01105.pdf | 1.61 MB | Adobe PDF | View/Open |
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