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http://hdl.handle.net/10397/105291
Title: | Quantitative spatial characterization of lymph node tumor for N stage improvement of nasopharyngeal carcinoma patients | Authors: | Zhang, J Teng, X Lam, S Sun, J Cheung, ALY Ng, SCY Lee, FKH Au, KH Yip, CWY Lee, VHF Lin, Z Liang, Y Yang, R Han, Y Zhang, Y Kong, FMS Cai, J |
Issue Date: | Jan-2023 | Source: | Cancers, Jan. 2023, v. 15, no. 1, 230 | Abstract: | This study aims to investigate the feasibility of improving the prognosis stratification of the N staging system of Nasopharyngeal Carcinoma (NPC) from quantitative spatial characterizations of metastatic lymph node (LN) for NPC in a multi-institutional setting. A total of 194 and 284 NPC patients were included from two local hospitals as the discovery and validation cohort. Spatial relationships between LN and the surrounding organs were quantified by both distance and angle histograms, followed by principal component analysis. Independent prognostic factors were identified and combined with the N stage into a new prognostic index by univariate and multivariate Cox regressions on disease-free survival (DFS). The new three-class risk stratification based on the constructed prognostic index demonstrated superior cross-institutional performance in DFS. The hazard ratios of the high-risk to low-risk group were 9.07 (p < 0.001) and 4.02 (p < 0.001) on training and validation, respectively, compared with 5.19 (p < 0.001) and 1.82 (p = 0.171) of N3 to N1. Our spatial characterizations of lymph node tumor anatomy improved the existing N-stage in NPC prognosis. Our quantitative approach may facilitate the discovery of new anatomical characteristics to improve patient staging in other diseases. | Keywords: | Lymph node tumor N stage Nasopharyngeal carcinoma Tumor geometry |
Publisher: | MDPI AG | Journal: | Cancers | EISSN: | 2072-6694 | DOI: | 10.3390/cancers15010230 | Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). The following publication Zhang J, Teng X, Lam S, Sun J, Cheung AL-Y, Ng SC-Y, Lee FK-H, Au K-H, Yip CW-Y, Lee VH-F, et al. Quantitative Spatial Characterization of Lymph Node Tumor for N Stage Improvement of Nasopharyngeal Carcinoma Patients. Cancers. 2023; 15(1):230 is available at https://doi.org/10.3390/cancers15010230. |
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