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http://hdl.handle.net/10397/105265
Title: | Evaluating the safety and efficacy of transcranial pulse stimulation on autism spectrum disorder : a double-blinded, randomized, sham-controlled trial protocol | Authors: | Cheung, T Ho, YS Fong, KH Lam, YTJ Li, MH Tse, ACY Li, CT Cheng, CPW Beisteiner, R |
Issue Date: | Dec-2022 | Source: | International journal of environmental research and public health, Dec. 2022, v. 19, no. 23, 15614 | Abstract: | Autistic spectrum disorder (ASD) is a common developmental disorder in children. The latest non-intrusive brain stimulation (NIBS) technology—transcranial pulse stimulation (TPS)—has been proven effective in older adults with mild neurocognitive disorders and adults with major depressive disorder. Nonetheless, there is so far no robust randomized controlled trial (RCT) conducted on adolescents with ASD nationwide. This study proposes a two-armed (verum TPS group vs. sham TPS group), double-blinded, randomized, sham-controlled trial. Both groups will be measured at four timepoints, namely, baseline (T1), 2 weeks immediately after post-TPS intervention (T2), and at the 1-month (T3) and 3-month (T4) follow-ups. Thirty-four subjects, aged between 12 and 17, diagnosed with ASD will be recruited in this study. All subjects will be computerized randomised into the verum TPS group or the sham TPS group on a 1:1 ratio. All subjects will undertake functional MRI (fMRI) before and after the 2-weeks TPS interventions, which will be completed in 2 weeks’ time. This will be the first RCT evaluating the efficacy of TPS adolescents with ASD in Hong Kong. | Keywords: | Adolescents Autism spectrum disorder Efficacy Neuromodulation RCT Transcranial pulse stimulation |
Publisher: | Molecular Diversity Preservation International (MDPI) | Journal: | International journal of environmental research and public health | ISSN: | 1661-7827 | EISSN: | 1660-4601 | DOI: | 10.3390/ijerph192315614 | Rights: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). The following publication Cheung T, Ho YS, Fong KH, Lam YTJ, Li MH, Tse AC-Y, Li C-T, Cheng CP-W, Beisteiner R. Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol. International Journal of Environmental Research and Public Health. 2022; 19(23):15614 is available at https://doi.org/10.3390/ijerph192315614. |
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