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Title: | Olfactory dysfunction : a plausible source of COVID-19-induced neuropsychiatric symptoms | Authors: | Tai, APL Leung, MK Lau, BWM Ngai, SPC Lau, WKW |
Issue Date: | 2023 | Source: | Frontiers in neuroscience, 2023, v. 17, 1156914 | Abstract: | Olfactory dysfunction and neuropsychiatric symptoms are commonly reported by patients of coronavirus disease 2019 (COVID-19), a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence from recent research suggests linkages between altered or loss of smell and neuropsychiatric symptoms after infection with the coronavirus. Systemic inflammation and ischemic injury are believed to be the major cause of COVID-19-related CNS manifestation. Yet, some evidence suggest a neurotropic property of SARS-CoV-2. This mini-review article summarizes the neural correlates of olfaction and discusses the potential of trans-neuronal transmission of SARS-CoV-2 or its particles within the olfactory connections in the brain. The impact of the dysfunction in the olfactory network on the neuropsychiatric symptoms associated with COVID-19 will also be discussed. | Keywords: | COVID-19 Nervus terminalis Neuropsychiatric symptoms Olfactory system Trans-neuronal viral transmission |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in neuroscience | ISSN: | 1662-453X | DOI: | 10.3389/fnins.2023.1156914 | Rights: | Copyright © 2023 Tai, Leung, Lau, Ngai and Lau. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Tai APL, Leung MK, Lau BMW, Ngai SPC and Lau WKW (2023) Olfactory dysfunction: A plausible source of COVID-19-induced neuropsychiatric symptoms. Front. Neurosci. 17:1156914 is available at https://doi.org/10.3389/fnins.2023.1156914. |
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