Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/105231
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Jin, N | - |
dc.creator | Kan, CM | - |
dc.creator | Pei, XM | - |
dc.creator | Cheung, WL | - |
dc.creator | Ng, SSM | - |
dc.creator | Wong, HT | - |
dc.creator | Cheng, HYL | - |
dc.creator | Leung, WW | - |
dc.creator | Wong, YN | - |
dc.creator | Tsang, HF | - |
dc.creator | Chan, AKC | - |
dc.creator | Wong, YKE | - |
dc.creator | Cho, WCS | - |
dc.creator | Chan, JKC | - |
dc.creator | Tai, WCS | - |
dc.creator | Chan, TF | - |
dc.creator | Wong, SCC | - |
dc.creator | Yim, AKY | - |
dc.creator | Yu, ACS | - |
dc.date.accessioned | 2024-04-12T06:50:54Z | - |
dc.date.available | 2024-04-12T06:50:54Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/105231 | - |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Research Foundation | en_US |
dc.rights | Copyright © 2023 Jin, Kan, Pei, Cheung, Ng, Wong, Cheng, Leung, Wong, Tsang, Chan, Wong, Cho, Chan, Tai, Chan, Wong, Yim and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights | The following publication Jin N, Kan C-M, Pei XM, Cheung WL, Ng SSM, Wong HT, Cheng HY-L, Leung WW, Wong YN, Tsang HF, Chan AKC, Wong YKE, Cho WCS, Chan JKC, Tai WCS, Chan T-F, Wong SCC, Yim AK-Y and Yu AC-S (2023) Cell-free circulating tumor RNAs in plasma as the potential prognostic biomarkers in colorectal cancer. Front. Oncol. 13:1134445 is available at https://doi.org/10.3389/fonc.2023.1134445. | en_US |
dc.subject | Cell-free circulating tumor RNAs | en_US |
dc.subject | Colorectal (colon) cancer | en_US |
dc.subject | CRC prognostic biomarkers | en_US |
dc.subject | RNA sequencing (RNA-seq) | en_US |
dc.subject | Transcriptome (RNA-seq) | en_US |
dc.title | Cell-free circulating tumor RNAs in plasma as the potential prognostic biomarkers in colorectal cancer | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 13 | - |
dc.identifier.doi | 10.3389/fonc.2023.1134445 | - |
dcterms.abstract | Background: Cell free RNA (cfRNA) contains transcript fragments from multiple cell types, making it useful for cancer detection in clinical settings. However, the pathophysiological origins of cfRNAs in plasma from colorectal cancer (CRC) patients remain unclear. | - |
dcterms.abstract | Methods: To identify the tissue-specific contributions of cfRNAs transcriptomic profile, we used a published single-cell transcriptomics profile to deconvolute cell type abundance among paired plasma samples from CRC patients who underwent tumor-ablative surgery. We further validated the differentially expressed cfRNAs in 5 pairs of CRC tumor samples and adjacent tissue samples as well as 3 additional CRC tumor samples using RNA-sequencing. | - |
dcterms.abstract | Results: The transcriptomic component from intestinal secretory cells was significantly decreased in the in-house post-surgical cfRNA. The HPGD, PACS1, and TDP2 expression was consistent across cfRNA and tissue samples. Using the Cancer Genome Atlas (TCGA) CRC datasets, we were able to classify the patients into two groups with significantly different survival outcomes. | - |
dcterms.abstract | Conclusions: The three-gene signature holds promise in applying minimal residual disease (MRD) testing, which involves profiling remnants of cancer cells after or during treatment. Biomarkers identified in the present study need to be validated in a larger cohort of samples in order to ascertain their possible use in early diagnosis of CRC. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Frontiers in oncology, 2023, v. 13, 1134445 | - |
dcterms.isPartOf | Frontiers in oncology | - |
dcterms.issued | 2023 | - |
dc.identifier.scopus | 2-s2.0-85153520338 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.artn | 1134445 | - |
dc.description.validate | 202403 bcvc | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | en_US |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Lim Peng Suan Charitable Trust Research Grant; HK Innovation and Technology Fund University-Industry Collaborative Programme | en_US |
dc.description.pubStatus | Published | en_US |
dc.description.oaCategory | CC | en_US |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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fonc-13-1134445.pdf | 5.62 MB | Adobe PDF | View/Open |
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