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http://hdl.handle.net/10397/105214
Title: | Low frequency repetitive transcranial magnetic stimulation promotes plasticity of the visual cortex in adult amblyopic rats | Authors: | Zheng, J Zhang, W Liu, L Yap, MKH |
Issue Date: | 2023 | Source: | Frontiers in neuroscience, 2023, v. 17, 1109735 | Abstract: | The decline of visual plasticity restricts the recovery of visual functions in adult amblyopia. Repetitive transcranial magnetic stimulation (rTMS) has been shown to be effective in treating adult amblyopia. However, the underlying mechanisms of rTMS on visual cortex plasticity remain unclear. In this study, we found that low-frequency rTMS reinstated the amplitude of visual evoked potentials, but did not influence the impaired depth perception of amblyopic rats. Furthermore, the expression of synaptic plasticity genes and the number of dendritic spines were significantly higher in amblyopic rats which received rTMS when compared with amblyopic rats which received sham stimulation, with reduced level of inhibition and perineuronal nets in visual cortex, as observed via molecular and histological investigations. The results provide further evidence that rTMS enhances functional recovery and visual plasticity in an adult amblyopic animal model. | Keywords: | Amblyopia GABA Perineuronal nets Repetitive transcranial magnetic stimulation Visual plasticity |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in neuroscience | ISSN: | 1662-453X | DOI: | 10.3389/fnins.2023.1109735 | Rights: | Copyright © 2023 Zheng, Zhang, Liu and Hung Yap. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Zheng J, Zhang W, Liu L and Hung Yap MK (2023) Low frequency repetitive transcranial magnetic stimulation promotes plasticity of the visual cortex in adult amblyopic rats. Front. Neurosci. 17:1109735 is available at https://doi.org/10.3389/fnins.2023.1109735. |
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