Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/104929
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Wang, J | en_US |
dc.creator | Zhang, B | en_US |
dc.creator | Chen, X | en_US |
dc.creator | Xin, Y | en_US |
dc.creator | Li, K | en_US |
dc.creator | Zhang, C | en_US |
dc.creator | Tang, K | en_US |
dc.creator | Tan. Y | en_US |
dc.date.accessioned | 2024-03-05T08:38:46Z | - |
dc.date.available | 2024-03-05T08:38:46Z | - |
dc.identifier.issn | 1742-7061 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/104929 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier BV | en_US |
dc.subject | Actomyosin, Motility | en_US |
dc.subject | Cell mechanics | en_US |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Metastasis | en_US |
dc.title | Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 321 | en_US |
dc.identifier.epage | 323 | en_US |
dc.identifier.volume | 176 | en_US |
dc.identifier.doi | 10.1016/j.actbio.2024.01.024 | en_US |
dcterms.abstract | Hepatocellular carcinoma (HCC) cells, especially those with metastatic competence, show reduced stiffness compared to the non-malignant counterparts. However, it is still unclear whether and how the mechanics of HCC cells influence their migration and invasion. This study reports that HCC cells with enhanced motility show reduced mechanical stiffness and cytoskeleton, suggesting the inverse correlation between cellular stiffness and motility. Through pharmacologic and genetic approaches, inhibiting actomyosin activity reduces HCC cellular stiffness but promotes their migration and invasion, while activating it increases cell stiffness but impairs cell motility. Actomyosin regulates cell motility through the influence on cellular stiffness. Mechanistically, weakening/strengthening cells inhibits/promotes c-Jun N terminal kinase (JNK) phosphorylation, activation/inhibition of which rescues the effects of cell mechanics on their migration and invasion. Further, HCC cancer stem cells (CSCs) exhibit higher motility but lower stiffness than control cells. Increasing CSC stiffness weakens migration and invasion through the activation of JNK signaling. In conclusion, our findings unveil a new regulatory role of actomyosin-mediated cellular mechanics in tumor cell motility and present new evidence to support that tumor cell softening may be one driving force for HCC metastasis. | en_US |
dcterms.accessRights | embargoed access | en_US |
dcterms.bibliographicCitation | Acta biomaterialia, 1 Mar. 2024, v. 176, p. 321-333 | en_US |
dcterms.isPartOf | Acta biomaterialia | en_US |
dcterms.issued | 2024-03-01 | - |
dc.identifier.eissn | 1878-7568 | en_US |
dc.description.validate | 202403 bcch | en_US |
dc.description.oa | Not applicable | en_US |
dc.identifier.FolderNumber | a2628 | - |
dc.identifier.SubFormID | 47974 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.pubStatus | Published | en_US |
dc.date.embargo | 2026-03-01 | en_US |
dc.description.oaCategory | Green (AAM) | en_US |
Appears in Collections: | Journal/Magazine Article |
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