Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/101564
PIRA download icon_1.1View/Download Full Text
DC FieldValueLanguage
dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorLai, WFen_US
dc.creatorWong, WTen_US
dc.date.accessioned2023-09-18T07:31:06Z-
dc.date.available2023-09-18T07:31:06Z-
dc.identifier.issn0167-7799en_US
dc.identifier.urihttp://hdl.handle.net/10397/101564-
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.rights© 2018 Elsevier Ltd. All rights reserved.en_US
dc.rights© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.rightsThe following publication Lai, W. F., & Wong, W. T. (2018). Design of polymeric gene carriers for effective intracellular delivery. Trends in biotechnology, 36(7), 713-728 is available at https://doi.org/10.1016/j.tibtech.2018.02.006.en_US
dc.titleDesign of polymeric gene carriers for effective intracellular deliveryen_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage713en_US
dc.identifier.epage728en_US
dc.identifier.volume36en_US
dc.identifier.issue7en_US
dc.identifier.doi10.1016/j.tibtech.2018.02.006en_US
dcterms.abstractPolymeric carriers have emerged as major non-viral alternatives for gene delivery due to their lower immunogenicity and pathogenicity. However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of gene delivery will be impeded. A thorough understanding of these cellular impediments is pivotal to optimizing the efficiency of polymer-based gene delivery. This review delineates the major barriers encountered during intracellular delivery of polyplexes and discusses possible molecular designs to overcome these barriers. Based on a review of the latest strategies to enhance the intracellular delivery process, we provide insights into the further development of polymeric carriers with enhanced efficiency in transfection.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationTrends in biotechnology, July 2018, v. 36, no. 7, p. 713-728en_US
dcterms.isPartOfTrends in biotechnologyen_US
dcterms.issued2018-07-
dc.identifier.scopus2-s2.0-85042847586-
dc.identifier.pmid29525137-
dc.identifier.eissn1879-3096en_US
dc.description.validate202308 bckwen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberABCT-0525-
dc.description.fundingSourceOthersen_US
dc.description.fundingTextShenzhen Science and Technology Innovation Committee; Natural Science Foundation of Shenzhen Universityen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS50633994-
dc.description.oaCategoryGreen (AAM)en_US
Appears in Collections:Journal/Magazine Article
Files in This Item:
File Description SizeFormat 
Wong_Design_Polymeric_Gene.pdfPre-Published version1.02 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Final Accepted Manuscript
Access
View full-text via PolyU eLinks SFX Query
Show simple item record

Page views

66
Citations as of Apr 14, 2025

Downloads

105
Citations as of Apr 14, 2025

SCOPUSTM   
Citations

125
Citations as of Dec 19, 2025

WEB OF SCIENCETM
Citations

111
Citations as of Dec 18, 2025

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.