Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/101547
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dc.contributorDepartment of Applied Biology and Chemical Technologyen_US
dc.creatorLiu, Yen_US
dc.creatorSun, Hen_US
dc.creatorHuang, Zen_US
dc.creatorMa, Cen_US
dc.creatorLin, Aen_US
dc.creatorYao, Hen_US
dc.creatorXu, Jen_US
dc.creatorXu, Sen_US
dc.date.accessioned2023-09-18T07:30:55Z-
dc.date.available2023-09-18T07:30:55Z-
dc.identifier.issn0022-3263en_US
dc.identifier.urihttp://hdl.handle.net/10397/101547-
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.rights© 2018 American Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in The Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.joc.8b01956.en_US
dc.titleMetal-free synthesis of N-(pyridine-2-yl)amides from ketones via selective oxidative cleavage of C(O)–C(alkyl) bond in wateren_US
dc.typeJournal/Magazine Articleen_US
dc.identifier.spage14307en_US
dc.identifier.epage14313en_US
dc.identifier.volume83en_US
dc.identifier.issue23en_US
dc.identifier.doi10.1021/acs.joc.8b01956en_US
dcterms.abstractThe TBHP/TBAI-mediated synthesis of N-(pyridine-2-yl)amides in water from ketones and 2-aminopyridine via direct oxidative C-C bond cleavage has been developed. A series of ketones, including more challenging inactive aromatic ketones substituted with diverse long-chain alkyl groups, were selectively converted to N-(pyridine-2-yl)amides. Furthermore, the protocol can be applied to aryl alkyl carbinols to afford the corresponding amides in moderate to good yields.en_US
dcterms.accessRightsopen accessen_US
dcterms.bibliographicCitationJournal of organic chemistry, 7 Dec. 2018, v. 83, no. 23, p. 14307-14313en_US
dcterms.isPartOfJournal of organic chemistryen_US
dcterms.issued2018-12-07-
dc.identifier.scopus2-s2.0-85058187138-
dc.identifier.pmid30450904-
dc.identifier.eissn1520-6904en_US
dc.description.validate202308 bckwen_US
dc.description.oaAccepted Manuscripten_US
dc.identifier.FolderNumberABCT-0469-
dc.description.fundingSourceRGCen_US
dc.description.fundingSourceOthersen_US
dc.description.fundingTextNational Natural Science Foundation of China; Project Program of State Key Laboratory of Natural Medicines; “Double First-Class” University project, China Pharmaceutical Universityen_US
dc.description.pubStatusPublisheden_US
dc.identifier.OPUS19747071-
dc.description.oaCategoryGreen (AAM)en_US
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