Palladium-phenylpyrazolylphosphine-catalyzed cross-coupling of alkenyl pivalates

Abstract

Palladium-catalyzed cross-coupling reactions are indispensable tools for C−C bond formation, and new catalyst development remains a powerful driving force in this field. In this study, a new type of easily accessible phenylpyrazole phosphine ligand is developed. The catalyst generated from Pd(OAc)2 and PP-Phos (L15) is highly effective in the palladium-catalyzed cross-coupling of alkenyl pivalates with organomagnesium reagents. The reaction accommodates a broad scope of alkenyl carboxylates under mild conditions, providing an alternative but practical way to the synthesis of multi-substituted alkenes in value.