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Title: Potential benefits of probiotics and prebiotics for coronary heart disease and stroke
Authors: Wu, H 
Chiou, J 
Issue Date: Aug-2021
Source: Nutrients, Aug. 2021, v. 13, no. 8, 2878
Abstract: Among cardiovascular diseases (CVDs), a major cause of morbidity and mortality worldwide, coronary heart disease and stroke are the most well‐known and extensively studied. The onset and progression of CVD is associated with multiple risk factors, among which, gut mi-crobiota has received much attention in the past two decades. Gut microbiota, the microbial community colonizing in the gut, plays a prominent role in human health. In particular, gut dysbiosis is directly related to many acute or chronic dysfunctions of the cardiovascular system (CVS) in the host. Earlier studies have demonstrated that the pathogenesis of CVD is strongly linked to intestinal microbiota imbalance and inflammatory responses. Probiotics and prebiotics conferring vari-ous health benefits on the host are emerging as promising therapeutic interventions for many dis-eases. These two types of food supplements have the potential to alleviate the risks of CVD through improving the levels of several cardiovascular markers, such as total and low‐density lipoprotein (LDL) cholesterol, high sensitivity C‐reactive protein (hs‐CRP), and certain cytokines involved in the inflammatory response. In this review, we focus mainly on the preventive effects of probiotics and prebiotics on CVD via rebalancing the structural and functional changes in gut microbiota and maintaining immune homeostasis.
Keywords: CVD
Gut microbiota
Immune homeostasis
Prebiotics
Probiotics
Publisher: Molecular Diversity Preservation International (MDPI)
Journal: Nutrients 
ISSN: 2072-6643
DOI: 10.3390/nu13082878
Rights: © 2021 by the authors.Licensee MDPI, Basel, Switzerland.This article is an open access articledistributed under the terms andconditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
The following publication Wu, H.; Chiou, J. PotentialBenefits of Probiotics and Prebioticsfor Coronary Heart Disease andStroke. Nutrients 2021, 13, 2878 is available at https://doi.org/10.3390/nu13082878
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