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Title: Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring
Authors: Yau, SY 
Yip, YSL 
Formolo, DA 
He, S 
Lee, THY 
Wen, C 
Hryciw, DH
Issue Date: Jan-2021
Source: Behavioural brain research, 7 Jan. 2022, v. 416, 113538
Abstract: Polyunsaturated fatty acids (PUFAs) play an essential role in brain development. Emerging data have suggested a possible link between an imbalance in PUFAs and cognitive behavioral deficits in offspring. A diet rich in high linoleic acid (HLA), typically from preconception to lactation, leads to an increase in the ratio of omega-6 (n-6) to omega-3 (n-3) fatty acids in the fetus. Arising research has suggested that a deficiency in omega-3 fatty acids is a potential risk factor for inducing autism spectrum disorder (ASD)-like behavioral deficits. However, the impact of a high n- diet during preconception, pregnancy, lactation, and post-weaning on the brain development of adolescent offspring are yet to be determined. This study examined whether consumption of an HLA diet during pregnancy, lactation, and post-weaning induced social and cognitive impairments in female and male offspring rats that resemble autistic phenotypes in humans. Female Wistar Kyoto rats were fed with either HLA or low linoleic acid (LLA) control diet for 10 weeks before mating, then continued with the same diet throughout the pregnancy and lactation period. Female and male offspring at 5 weeks old were subjected to behavioral tests to assess social interaction behavior and depression-/anxiety-like behavior. Our result showed that chronic consumption of an HLA diet did not affect sociability and social recognition memory, but induced depression-like behavior in male but not in female offspring.
Keywords: Autism spectrum disorder
Depression-like behavior
Linoleic acid
Maternal diet
Nutrition
Offspring
Publisher: Elsevier
Journal: Behavioural brain research 
ISSN: 0166-4328
EISSN: 1872-7549
DOI: 10.1016/j.bbr.2021.113538
Rights: © 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
The following publication Yau, S. Y., Yip, Y. S. L., Formolo, D. A., He, S., Lee, T. H. Y., Wen, C., & Hryciw, D. H. (2022). Chronic consumption of a high linoleic acid diet during pregnancy, lactation and post-weaning period increases depression-like behavior in male, but not female offspring. Behavioural Brain Research, 416, 113538 is available at https://doi.org/10.1016/j.bbr.2021.113538
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