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Title: Hampering stromal cells in the tumor microenvironment as a therapeutic strategy to destem cancer stem cells
Authors: Chung, KPS 
Leung, RWH 
Lee, TKW 
Issue Date: Jul-2021
Source: Cancers, July 2021, v. 13, no. 13, 3191
Abstract: Cancer stem cells (CSCs) within the tumor bulk play crucial roles in tumor initiation, recurrence and therapeutic resistance. In addition to intrinsic regulation, a growing body of evidence suggests that the phenotypes of CSCs are also regulated extrinsically by stromal cells in the tumor microenvironment (TME). Here, we discuss the current knowledge of the interplay between stromal cells and cancer cells with a special focus on how stromal cells drive the stemness of cancer cells and immune evasive mechanisms of CSCs. Knowledge gained from the interaction between CSCs and stromal cells will provide a mechanistic basis for the development of novel therapeutic strategies for the treatment of cancers.
Keywords: Cancer
Cancer stem cells
Immune cells
Stromal cells
Tumor microenvironment
Publisher: MDPI AG
Journal: Cancers 
EISSN: 2072-6694
DOI: 10.3390/cancers13133191
Rights: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
The following publication Chung, K.P.S.; Leung, R.W.H.; Lee, T.K.W. Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells. Cancers 2021, 13, 3191 is available at https://doi.org/10.3390/cancers13133191
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