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Title: Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) pneumonia : a case-control study
Authors: Li, N
Han, L 
Peng, M
Lv, Y
Ouyang, Y
Liu, K
Yue, L
Li, Q
Sun, G
Chen, L
Yang, L 
Issue Date: Oct-2020
Source: Clinical infectious diseases, 15 Oct. 2020, v. 71, no. 16, p. 2035-2041
Abstract: Background: The ongoing pandemic of coronavirus disease 2019 (COVID-19) has caused serious concerns about its potential adverse effects on pregnancy. There are limited data on maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia.
Methods: We conducted a case-control study to compare clinical characteristics and maternal and neonatal outcomes of pregnant women with and without COVID-19 pneumonia.
Results: During the period 24 January-29 February 2020, there were 16 pregnant women with confirmed COVID-19 pneumonia and 18 suspected cases who were admitted to labor in the third trimester. Two had vaginal delivery and the rest were cesarean delivery. Few patients presented respiratory symptoms (fever and cough) on admission, but most had typical chest computed tomographic images of COVID-19 pneumonia. Compared to the controls, patients with COVID-19 pneumonia had lower counts of white blood cells (WBCs), neutrophils, C-reactive protein (CRP), and alanine aminotransferase on admission. Increased levels of WBCs, neutrophils, eosinophils, and CRP were found in postpartum blood tests of pneumonia patients. Three (18.8%) of the mothers with confirmed COVID-19 pneumonia and 3 (16.7%) with suspected COVID-19 pneumonia had preterm delivery due to maternal complications, which were significantly higher than in the control group. None experienced respiratory failure during their hospital stay. COVID-19 infection was not found in the newborns, and none developed severe neonatal complications.
Conclusions: Severe maternal and neonatal complications were not observed in pregnant women with COVID-19 pneumonia who had vaginal or cesarean delivery. Mild respiratory symptoms of pregnant women with COVID-19 pneumonia highlight the need of effective screening on admission.
Keywords: COVID-19
Maternal outcomes
Neonates
Pregnancy
Vaginal delivery
Publisher: Oxford University Press
Journal: Clinical infectious diseases 
ISSN: 1058-4838
EISSN: 1537-6591
DOI: 10.1093/cid/ciaa352
Rights: © 2020 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical infectious diseases following peer review. The version of recordLi, N., Han, L., Peng, M., Lv, Y., Ouyang, Y., Liu, K., ... & Yang, L. (2020). Maternal and neonatal outcomes of pregnant women with coronavirus disease 2019 (COVID-19) pneumonia: a case-control study. Clinical infectious diseases, 71(16), 2035-2041. is available online at: https://doi.org/10.1093/cid/ciaa352.
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