Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/89276
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Title: Chiral cyclometalated oxazoline gold(III) complex-catalyzed asymmetric carboalkoxylation of alkynes
Authors: Jiang, JJ 
Cui, JF 
Yang, B 
Ning, Y 
Lai, NCH 
Wong, MK 
Issue Date: 6-Aug-2019
Source: Organic letters, 6 Aug. 2019, v. 21, no. 16, p. 6289-6294
Abstract: Asymmetric catalysis by using novel chiral O,O′-chelated 4,4′-biphenol cyclometalated oxazoline gold(III) complexes has been developed. A high yield (≤89%) and a high enantioselectivity (≤90% ee) were achieved in asymmetric carboalkoxylation of alkynes. Enantioselectivity could be significantly improved from 19% to 90% ee by increasing the steric size of the substituent on the chiral oxazoline ligand. Catalytically active AuIII species and the origin of chiral induction are proposed.
Publisher: American Chemical Society
Journal: Organic letters 
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/acs.orglett.9b02171
Rights: © 2019 American Chemical Society
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see https://pubs.acs.org/doi/10.1021/acs.orglett.9b02171
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