Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/88448
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Title: In situ deposition of MOF-74(Cu) nanosheet arrays onto carbon cloth to fabricate a sensitive and selective electrocatalytic biosensor and its application for the determination of glucose in human serum
Authors: Hu, S 
Lin, Y
Teng, J
Wong, W 
Qiu, B
Issue Date: 2020
Source: Microchimica acta, 2020, v. 187, 670, p. 1-10
Abstract: A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/N = 3). The response sensitivity is 3.35 mA mM−1 cm−2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM−1 cm−2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors.
Keywords: MOF-74(Cu)
Two-dimensional metal-organic framework nanosheet
Bottom-up synthesis
In situ deposition
Carbon cloth
Electrochemical catalysis
Electrochemical biosensor
Glucose sensor
Glucose oxidation
Non-enzymaticmethod
Publisher: Springer
Journal: Microchimica acta 
ISSN: 0026-3672
DOI: 10.1007/s00604-020-04634-8
Rights: © Springer-Verlag GmbH Austria, part of Springer Nature 2020
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use (https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms), but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00604-020-04634-8
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