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Title: Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression : a 2-year randomised clinical trial
Authors: Lam, CSY 
Tang, WC 
Tse, DYY 
Lee, RPK 
Chun, RKM 
Hasegawa, K
Qi, H
Hatanaka, T
To, CH 
Issue Date: Mar-2020
Source: British journal of ophthalmology, Mar. 2020, v. 104, no. 3, p. 363-368
Abstract: Aim: To determine if 'Defocus Incorporated Multiple Segments' (DIMS) spectacle lenses slow childhood myopia progression.
Methods: A 2-year double-masked randomised controlled trial was carried out in 183 Chinese children aged 8-13 years, with myopia between -1.00 and -5.00 D and astigmatism <= 1.50 D. Children were randomly assigned to wear DIMS (n=93) or single vision (SV) spectacle lenses (n=90). DIMS lens incorporated multiple segments with myopic defocus of +3.50 D. Refractive error (cycloplegic autorefraction) and axial length were measured at 6month intervals.
Results: 160 children completed the study, n=79 in the DIMS group and n=81 in the SV group. Average (SE) myopic progressions over 2 years were -0.41 +/- 0.06 D in the DIMS group and -0.85 +/- 0.08 D in the SV group. Mean (SE) axial elongation was 0.21 +/- 0.02 mm and 0.55 +/- 0.02 mm in the DIMS and SV groups, respectively. Myopia progressed 52% more slowly for children in the DIMS group compared with those in the SV group (mean difference -0.44 +/- 0.09 D, 95% CI -0.73 to -0.37, p<0.0001). Likewise, children in the DIMS group had less axial elongation by 62% than those in the SV group (mean difference 0.34 +/- 0.04 mm, 95% CI 0.22 to 0.37, p<0.0001). 21.5% children who wore DIMS lenses had no myopia progression over 2 years, but only 7.4% for those who wore SV lenses.
Conclusions: Daily wear of the DIMS lens significantly retarded myopia progression and axial elongation in myopic children. Our results demonstrated simultaneous clear vision with constant myopic defocus can slow myopia progression.
Publisher: BMJ Publishing Group
Journal: British journal of ophthalmology 
ISSN: 0007-1161
EISSN: 1468-2079
DOI: 10.1136/bjophthalmol-2018-313739
Rights: © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
The following publication Lam, C. S. Y., Tang, W. C., Tse, D. Y. Y., Lee, R. P. K., Chun, R. K. M., Hasegawa, K., ... & To, C. H. (2020). Defocus Incorporated Multiple Segments (DIMS) spectacle lenses slow myopia progression: a 2-year randomised clinical trial. British Journal of Ophthalmology, 104(3), 363-368 is available at https://dx.doi.org/10.1136/bjophthalmol-2018-313739
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