Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7580
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Title: Predictors of success in selective laser trabeculoplasty for normal tension glaucoma
Authors: Lee, JWY
Liu, CCL 
Chan, JCH
Lai, JSM
Issue Date: 2014
Source: Medicine, 2014, v. 93, no. 28, p. e236-
Abstract: To determine the predictors of success for selective laser trabeculoplasty (SLT) in normal tension glaucoma (NTG).This prospective cohort study recruited subjects with unilateral or bilateral NTG on medication. All subjects received a single session of 360° SLT treatment. SLT success was defined as IOP reduction ≥20% at 1-month. The following covariates were analyzed via univariate and multivariate analyses: age; sex; lens status; presenting, pre-SLT, and post-SLT IOP's; number and type of medications; SLT shots and energy; and pre-SLT investigations.In 60 eyes of 32 subjects with NTG, there were 30 right eyes and 28 left eyes. The success rate of SLT was 61.7%. Using 3 types of anti-glaucoma medications (coefficient = -2.2, OR = 0.1, P = 0.02) and a thicker retinal nerve fiber layer thickness (coefficient = -0.04, OR = 0.96, P = 0.04) were associated with failure (univariate analysis). In multivariate analysis, a higher pre-SLT IOP (coefficient = 1.1, OR = 3.1, P = 0.05) and a lower 1-week IOP (coefficient = -0.8, OR = 0.5, P = 0.04) were associated with success.SLT was successful in over 60% of treated NTG patients. A higher pre-SLT IOP and a greater IOP reduction at 1-week post-SLT were predictors of a successful outcome.
Publisher: Lippincott Williams & Wilkins
Journal: Medicine 
ISSN: 0025-7974
EISSN: 1536-5964
DOI: 10.1097/MD.0000000000000236
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