Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/7571
PIRA download icon_1.1View/Download Full Text
Title: Nanotherapeutics in angiogenesis : synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos
Authors: Cheng, J
Gu, YJ
Wang, Y
Cheng, SH
Wong, WT 
Issue Date: Sep-2011
Source: International journal of nanomedicine, Sep 2011, v. 2011:6, p. 2007-2021
Abstract: Background: Carbon nanotubes have shown broad potential in biomedical applications, given their unique mechanical, optical, and chemical properties. In this pilot study, carbon nanotubes have been explored as multimodal drug delivery vectors that facilitate antiangiogenic therapy in zebrafish embryos.
Methods: Three different agents, ie, an antiangiogenic binding site (cyclic arginine-glycin-easpartic acid), an antiangiogenic drug (thalidomide), and a tracking dye (rhodamine), were conjugated onto single-walled carbon nanotubes (SWCNT). The biodistribution, efficacy, and biocompatibility of these triple functionalized SWCNT were tested in mammalian cells and validated in transparent zebrafish embryos.
Results: Accumulation of SWCNT-associated nanoconjugates in blastoderm cells facilitated drug delivery applications. Mammalian cell xenograft assays demonstrated that these antiangiogenic SWCNT nanoconjugates specifically inhibited ectopic angiogenesis in the engrafted zebrafish embryos.
Conclusion: This study highlights the potential of using SWCNT for generating efficient nanotherapeutics.
Keywords: Carbon nanotubes
Drug delivery
Antiangiogenic therapy
Publisher: Dove Medical Press
Journal: International journal of nanomedicine 
ISSN: 1176-9114
EISSN: 1178-2013
DOI: 10.2147/IJN.S20145
Rights: © 2011 Cheng et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
Appears in Collections:Journal/Magazine Article

Files in This Item:
File Description SizeFormat 
Cheng_nanotherapeutics_angiogenesis_synthesis.pdf3.17 MBAdobe PDFView/Open
Open Access Information
Status open access
File Version Version of Record
Access
View full-text via PolyU eLinks SFX Query
Show full item record

Page views

106
Last Week
3
Last month
Citations as of Aug 7, 2022

Downloads

113
Citations as of Aug 7, 2022

SCOPUSTM   
Citations

26
Last Week
1
Last month
Citations as of Aug 4, 2022

WEB OF SCIENCETM
Citations

29
Last Week
0
Last month
0
Citations as of Aug 4, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.