Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/70851
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Title: Influence of autophagy on the efficacy of radiotherapy
Authors: Tam, SY 
Wu, VWC 
Law, HKW 
Issue Date: 2017
Source: Radiation oncology, 2017, v. 12, 57, p. 1-10
Abstract: Autophagy is an important catabolic process in which cells digest and recycle their own cytoplasmic contents for maintaining cellular homeostasis. Interestingly, autophagy could play both pro-death and pro-survival roles in influencing the development of cancer via various signal pathways. As radiotherapy is one of the main treatment modalities for cancer, we reviewed the effect of autophagy modulations on radiosensitivity and radiotherapy efficacy in various cancer types. The future development of autophagy modifications for improving radiotherapy efficacy and cancer prognosis will also be discussed.
Keywords: Autophagy
Radiotherapy
Signalling pathway
Radiotherapy efficacy
Radiosensitivity
Cancer Cell lines
Publisher: BioMed Central
Journal: Radiation oncology 
ISSN: 1748-717X
DOI: 10.1186/s13014-017-0795-y
Rights: © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
The following publication Tam, S. Y., Wu, V. W. C., & Law, H. K. W. (2017). Influence of autophagy on the efficacy of radiotherapy. Radiation Oncology, 12, 57, 1-10 is available at https://dx.doi.org/10.1186/s13014-017-0795-y
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