Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/67405
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Title: Cancer stem cells and their microenvironment : biology and therapeutic implications
Authors: Lau, E 
Ho, N 
Lee, T 
Issue Date: 2017
Source: Stem cells international, 2017, v. 2017, 3714190
Abstract: Tumor consists of heterogeneous cancer cells including cancer stem cells (CSCs) that can terminally differentiate into tumor bulk. Normal stem cells in normal organs regulate self-renewal within a stem cell niche. Likewise, accumulating evidence has also suggested that CSCs are maintained extrinsically within the tumor microenvironment, which includes both cellular and physical factors. Here, we review the significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance.With a better understanding of how CSC interacts with its niche, we are able to identify potential therapeutic targets for the development of more effective treatments against cancer.
Publisher: Hindawi
Journal: Stem cells international 
ISSN: 1687-966X
EISSN: 1687-9678
DOI: 10.1155/2017/3714190
Rights: Copyright © 2017 Eunice Yuen-Ting Lau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The following article: Lau, E. Y. T., Ho, N. P. Y., & Lee, T. K. W. (2017). Cancer stem cells and their microenvironment: biology and therapeutic implications. Stem cells international, 2017, is available at https//doi.org/10.1155/2017/3714190
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