Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/5076
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Title: Liver cancer immunoassay with magnetic nanoparticles and MgO-based magnetic tunnel junction sensors
Authors: Lei, ZQ
Li, L
Li, GJ
Leung, CW 
Shi, J
Wong, CM
Lo, KC
Chan, WK
Mak, CSK
Chan, SB
Chan, NMM
Leung, CH
Lai, PT
Pong, PWT
Issue Date: 1-Apr-2012
Source: Journal of applied physics, 1 Apr. 2012, v. 111, no. 7, 07E505, p. 1-3
Abstract: We have demonstrated the detection of alpha-fetoprotein (AFP) labeled with magnetic nanoparticles (MNPs) using MgO-based magnetic tunnel junction (MTJ) sensors. AFP is an important hepatic tumor biomarker and the detection of AFP has significant applications for clinical diagnostics and immunoassay for early-stage liver cancer indications. In this work, MgO-based MTJ sensors and 20-nm iron-oxide magnetic nanoparticles (MNPs) were used for detecting AFP antigens by a sandwich-assay configuration. The MTJ sensors with a sensing area of 4 × 2 μm² possess tunneling magnetoresistance (TMR) of 122% and sensitivity of 0.95%/Oe at room temperature. The target AFP antigens of three concentrations were successfully detected, and the experimental data indicate that the resistance variations of the MTJ sensor increased with the AFP concentration ratios proportionally. These results demonstrate that MgO-based MTJ sensors together with MNPs are a promising biosensing platform for liver cancer immunoassay.
Keywords: Biosensors
Cancer
Liver
Magnesium compounds
Magnetic particles
Nanomedicine
Nanoparticles
Proteins
Tumours
Tunnelling magnetoresistance
Publisher: American Institute of Physics
Journal: Journal of applied physics 
ISSN: 0021-8979
EISSN: 1089-7550
DOI: 10.1063/1.3676212
Rights: © 2012 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Z. Q. Lei et al., J. Appl. Phys. 111, 07E505 (2012) and may be found at http://link.aip.org/link/?jap/111/07E505.
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