Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/44029
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Title: Clam-inspired nanoparticle immobilization method using adhesive tape as microchip substrate
Authors: Huang, X 
Zhu, Y 
Zhang, X 
Bao, Z 
Lei, DY 
Yu, W
Dai, J 
Wang, Y 
Issue Date: 2016
Source: Sensors and actuators. B, Chemical, 2016, v. 222, p. 106-111
Abstract: Immobilization of the suspended nanoparticles is essential for many microfluidic applications. This work reports a novel biomimetic method to immobilize nanoparticles by using a common adhesive tape as the substrate of microfluidic chip. It mimics the clams' feeding system that utilizes the mucus (i.e., sticky fluid) to capture small phytoplankton particles in water. This work proves experimentally that this method has a better immobilization effect and a stronger shear stress resistance than the traditional methods using hard glass substrates. Moreover, we have applied this method to immobilize Au nanorods for the detection of R6G of various concentrations using the surface-enhanced Raman scattering (SERS) effect. This method enjoys several major merits: the sticky adhesive tape can seal the microfluidic structure easily, avoiding the bonding process; the immobilization is easy and environmental friendly, without the need for expensive reagents or complex processes; the adhesive tape substrate allows the flexibility of microfluidic chips; and the adhesive tape substrate can be stripped off for off-chip detection and can be replaced easily for the reuse of microfluidic structures. With these, the biomimetic method may find potential applications in environmental sensing, biocatalysis and biosynthesis using microchips.
Keywords: Biochip
Biomimetics
Microfabrication
Microfluidics
Nanoparticle immobilization
SERS
Publisher: Elsevier
Journal: Sensors and actuators. B, Chemical 
ISSN: 0925-4005
EISSN: 1873-3077
DOI: 10.1016/j.snb.2015.08.069
Rights: © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
The following publication Huang, X., Zhu, Y., Zhang, X., Bao, Z., Lei, D. Y., Yu, W., ... & Wang, Y. (2016). Clam-inspired nanoparticle immobilization method using adhesive tape as microchip substrate. Sensors and Actuators B: Chemical, 222, 106-111, is available at https://doi.org/10.1016/j.snb.2015.08.069
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