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Title: An optical coherence tomography (OCT)-based air jet indentation system for measuring the mechanical properties of soft tissues
Authors: Huang, YP 
Zheng, YP 
Wang, S
Chen, ZP
Huang, QH
He, YH
Issue Date: Jan-2009
Source: Measurement science and technology, Jan. 2009, v. 20, no. 1, 015805, p. [1-11]
Abstract: A novel noncontact indentation system with the combination of an air jet and optical coherence tomography (OCT) was presented in this paper for the quantitative measurement of the mechanical properties of soft tissues. The key idea of this method is to use a pressure-controlled air jet as an indenter to compress the soft tissue in a noncontact way and utilize the OCT signals to extract the deformation induced. This indentation system provides measurement and mapping of tissue elasticity for small specimens with high scanning speed. Experiments were performed on 27 silicone tissue-mimicking phantoms with different Young’s moduli, which were also measured by uniaxial compression tests. The regression coefficient of the indentation force to the indentation depth (N mm‾¹) was used as an indicator of the stiffness of tissue under air jet indentation. Results showed that the stiffness coefficients measured by the current system correlated well with the corresponding Young’s moduli obtained by conventional mechanical testing (r = 0.89, p < 0.001). Preliminary in vivo tests also showed that the change of soft tissue stiffness with and without the contraction of the underlying muscles in the hand could be differentiated by the current measurement. This system may have broad applications in tissue assessment and characterization where alterations of mechanical properties are involved, in particular with the potential of noncontact micro-indentation for tissues.
Keywords: Indentation
Ultrasound indentation
Soft tissue
Elasticity
Air jet
Optical coherence tomography
Publisher: Institute of Physics Publishing
Journal: Measurement science and technology 
ISSN: 0957-0233
EISSN: 1361-6501
DOI: 10.1088/0957-0233/20/1/015805
Rights: © 2009 IOP Publishing Ltd. This is an author-created, un-copyedited version of an article accepted for publication in Measurement Science and Technology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at doi: 10.1088/0957-0233/20/1/015805.
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