Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/96593
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | - |
dc.creator | Cheng, Y | en_US |
dc.creator | Kang, XZ | en_US |
dc.creator | Cheng, T | en_US |
dc.creator | Ye, ZW | en_US |
dc.creator | Tipoe, GL | en_US |
dc.creator | Yu, CH | en_US |
dc.creator | Wong, CM | en_US |
dc.creator | Liu, B | en_US |
dc.creator | Chan, CP | en_US |
dc.creator | Jin, DY | en_US |
dc.date.accessioned | 2022-12-07T02:55:32Z | - |
dc.date.available | 2022-12-07T02:55:32Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/96593 | - |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Inc. | en_US |
dc.rights | © 2022 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.rights | The following publication Cheng, Y., Kang, X. Z., Cheng, T., Ye, Z. W., Tipoe, G. L., Yu, C. H., ... & Jin, D. Y. (2022). FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity. Cellular and molecular gastroenterology and hepatology, 13(5), 1365-1391 is available at https://doi.org/10.1016/j.jcmgh.2022.01.017. | en_US |
dc.subject | Intestinal fat absorption | en_US |
dc.subject | Lipid homeostasis | en_US |
dc.subject | Metabolic syndrome | en_US |
dc.subject | Phospholipid-binding protein | en_US |
dc.subject | Recycling endosome | en_US |
dc.title | FACI is a novel CREB-H–induced protein that inhibits intestinal lipid absorption and reverses diet-induced obesity | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1365 | en_US |
dc.identifier.epage | 1391 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.doi | 10.1016/j.jcmgh.2022.01.017 | en_US |
dcterms.abstract | Background & Aims: CREB-H is a key liver-enriched transcription factor governing lipid metabolism. Additional targets of CREB-H remain to be identified and characterized. Here, we identified a novel fasting- and CREB-H–induced (FACI) protein that inhibits intestinal lipid absorption and alleviates diet-induced obesity in mice. | - |
dcterms.abstract | Methods: FACI was identified by reanalysis of existing transcriptomic data. Faci-/- mice were generated by clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9)-mediated genome engineering. RNA sequencing was performed to identify differentially expressed genes in Faci-/- mice. Lipid accumulation in the villi was assessed by triglyceride measurement and Oil red O staining. In vitro fatty acid uptake assay was performed to verify in vivo findings. | - |
dcterms.abstract | Results: FACI expression was enriched in liver and intestine. FACI is a phospholipid-binding protein that localizes to plasma membrane and recycling endosomes. Hepatic transcription of Faci was regulated by not only CREB-H, but also nutrient-responsive transcription factors sterol regulatory element-binding protein 1 (SREBP1), hepatocyte nuclear factor 4α (HNF4α), peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α), and CREB, as well as fasting-related cyclic adenosine monophosphate (cAMP) signaling. Genetic knockout of Faci in mice showed an increase in intestinal fat absorption. In accordance with this, Faci deficiency aggravated high-fat diet–induced obesity, hyperlipidemia, steatosis, and other obesity-related metabolic dysfunction in mice. | - |
dcterms.abstract | Conclusions: FACI is a novel CREB-H–induced protein. Genetic disruption of Faci in mice showed its inhibitory effect on fat absorption and obesity. Our findings shed light on a new target of CREB-H implicated in lipid homeostasis. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | CMGH, 2022, v. 13, no. 5, p. 1365-1391 | en_US |
dcterms.isPartOf | CMGH | en_US |
dcterms.issued | 2022 | - |
dc.identifier.scopus | 2-s2.0-85126628685 | - |
dc.identifier.pmid | 35093589 | - |
dc.identifier.eissn | 2352-345X | en_US |
dc.description.validate | 202212 bckw | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S2352345X22000170-main.pdf | 12.16 MB | Adobe PDF | View/Open |
Page views
66
Last Week
0
0
Last month
Citations as of May 19, 2024
Downloads
23
Citations as of May 19, 2024
SCOPUSTM
Citations
5
Citations as of May 16, 2024
WEB OF SCIENCETM
Citations
5
Citations as of May 16, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.