Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/96578
DC Field | Value | Language |
---|---|---|
dc.contributor | Mainland Development Office | - |
dc.contributor | Department of Applied Biology and Chemical Technology | - |
dc.creator | Kung, KKY | en_US |
dc.creator | Xu, CF | en_US |
dc.creator | O, WY | en_US |
dc.creator | Yu, Q | en_US |
dc.creator | Chung, SF | en_US |
dc.creator | Tam, SY | en_US |
dc.creator | Leung, YC | en_US |
dc.creator | Wong, MK | en_US |
dc.date.accessioned | 2022-12-07T02:55:29Z | - |
dc.date.available | 2022-12-07T02:55:29Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/96578 | - |
dc.language.iso | en | en_US |
dc.publisher | Royal Society of Chemistry | en_US |
dc.rights | © 2022 The Author(s). Published by the Royal Society of Chemistry | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/). | en_US |
dc.rights | The following publication Kung, K. K. Y., Xu, C. F., O, W. Y., Yu, Q., Chung, S. F., Tam, S. Y., ... & Wong, M. K. (2022). Functionalized quinolizinium-based fluorescent reagents for modification of cysteine-containing peptides and proteins. RSC advances, 12(10), 6248-6254 is available at https://doi.org/10.1039/D1RA08329E. | en_US |
dc.title | Functionalized quinolizinium-based fluorescent reagents for modification of cysteine-containing peptides and proteins | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 6248 | en_US |
dc.identifier.epage | 6254 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.doi | 10.1039/d1ra08329e | en_US |
dcterms.abstract | A series of quinolizinium-based fluorescent reagents were prepared by visible light-mediated gold-catalyzed cis-difunctionalization between quinolinium diazonium salts and electron-deficient alkyne-linked phenylethynyl trimethylsilanes. The electron-deficient alkynyl group of the quinolizinium-based fluorescent reagents underwent nucleophilic addition reaction with the sulfhydryl group on cysteine-containing peptides and proteins. The quinolizinium-based fluorescent reagents were found to function as highly selective reagents for the modification of cysteine-containing peptides and proteins with good to excellent conversions (up to 99%). Moreover, the modified BCArg mutants bearing cationic quinolizinium compounds 1b, 1d, 1e and 1h exhibit comparable activity in enzymatic and cytotoxicity assays to the unmodified one. | - |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | RSC advances, 2022, v. 12, no. 10, p. 6248-6254 | en_US |
dcterms.isPartOf | RSC advances | en_US |
dcterms.issued | 2022 | - |
dc.identifier.scopus | 2-s2.0-85126966727 | - |
dc.identifier.eissn | 2046-2069 | en_US |
dc.description.validate | 202212 bckw | - |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | OA_Scopus/WOS | - |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
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d1ra08329e.pdf | 523.62 kB | Adobe PDF | View/Open |
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