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http://hdl.handle.net/10397/96567
Title: | Water extract of rhizome drynaria selectively exerts estrogenic activities in ovariectomized rats and estrogen receptor-positive cells | Authors: | Zhou, L Wong, KY Poon, CCW Yu, W Xiao, H Chan, CO Mok, DKW Wong, MS |
Issue Date: | Feb-2022 | Source: | Frontiers in Endocrinology, Feb. 2022, v. 13, 817146 | Abstract: | Our previous study demonstrated that the bone protective actions of herbal medicine Rhizoma Drynariae (Gusuibu, RD) were mainly mediated by flavonoid phytoestrogens via estrogen receptors, raising concerns about the safety of using RD as it may induce estrogen-like risk-benefit profile and interact with other ER ligands, such as selective estrogen receptor modulators (SERMs), when coadministered. The present study evaluated the estrogenic activities of RD and its potential interaction with tamoxifen, a SERM, in estrogen-sensitive tissues by using mature ovariectomized (OVX) rats and ER-positive cells. Similar to but weaker than tamoxifen, RD at its clinical dose dramatically ameliorated OVX-induced changes in bone and dopamine metabolism-related markers in OVX rats. However, tamoxifen, but not RD, induced uterotrophic effects. No significant alteration in mammary gland was observed in OVX rats treated with RD, which was different from the inhibitory actions of tamoxifen. The two-way ANOVA results indicated the interactions between RD and tamoxifen in the bone, brain, and uterus of OVX rats while RD did not alter their responses to tamoxifen. Our results demonstrate that RD selectively exerts estrogenic actions in a different manner from tamoxifen. Moreover, RD interacts with tamoxifen without altering its effects in OVX rats. | Keywords: | Estrogen receptors Estrogenic activities Phytoestrogen Rhizoma drynaria Selective estrogen receptor modulators (SERMs) Tissue selectivity |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in Endocrinology | EISSN: | 1664-2392 | DOI: | 10.3389/fendo.2022.817146 | Rights: | © 2022 Zhou, Wong, Poon, Yu, Xiao, Chan, Mok and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Zhou, L., Wong, K. Y., Poon, C. C. W., Yu, W., Xiao, H., Chan, C. O., ... & Wong, M. S. (2022). Water Extract of Rhizoma Drynaria Selectively Exerts Estrogenic Activities in Ovariectomized Rats and Estrogen Receptor-Positive Cells. Frontiers in endocrinology, 13, 817146 is available at https://doi.org/10.3389/fendo.2022.817146. |
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