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http://hdl.handle.net/10397/96511
Title: | A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions | Authors: | Zheng, Y Gao, A Bai, J Liao, Q Wu, Y Zhang, W Guan, M Tong, L Geng, D Zhao, X Chu, PK Wang, H |
Issue Date: | Aug-2022 | Source: | Bioactive materials, Aug. 2022, v. 14, p. 364-376 | Abstract: | Polyetheretherketone (PEEK) is a desirable alternative to conventional biomedical metals for orthopedic implants due to the excellent mechanical properties. However, the inherent bioinertness of PEEK contributes to inferior osseointegration of PEEK implants, especially under pathological conditions of osteoporosis. Herein, a programmed surface is designed and fabricated on PEEK to dictate osteoimmunomodulation and bone regeneration sequentially. A degradable hybrid coating consisting of poly(lactide-co-glycolide) and alendronate (ALN) loaded nano-hydroxyapatite is deposited on PEEK and then interleukin-4 (IL-4) is grafted onto the outer surface of the hybrid coating with the aid of N2 plasma immersion ion implantation and subsequent immersion in IL-4 solution. Dominant release of IL-4 together with ALN and Ca2+ during the first few days synergistically mitigates the early acute inflammatory reactions and creates an osteoimmunomodulatory microenvironment that facilitates bone regeneration. Afterwards, slow and sustained delivery of ALN and Ca2+ in the following weeks boosts osteogenesis and suppresses osteoclastogenesis simultaneously, consequently ameliorating bone-implant osseointegration even under osteoporotic conditions. By taking into account the different phases in bone repair, this strategy of constructing advanced bone implants with sequential functions provides customizable and clinically viable therapy to osteoporotic patients. | Keywords: | Osseointegration Osteoimmunomodulation Osteoporosis Polyetheretherketone Sequential release Surface modification |
Publisher: | Ke Ai Publishing Communications Ltd. | Journal: | Bioactive materials | EISSN: | 2452-199X | DOI: | 10.1016/j.bioactmat.2022.01.042 | Rights: | © 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Zheng, Y., Gao, A., Bai, J., Liao, Q., Wu, Y., Zhang, W., ... & Wang, H. (2022). A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions. Bioactive materials, 14, 364-376 is available at https://doi.org/10.1016/j.bioactmat.2022.01.042. |
Appears in Collections: | Journal/Magazine Article |
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