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http://hdl.handle.net/10397/95775
Title: | Synthesis of 1H-isoindoliums by electrophile-mediated cascade cyclization/iodination of propargylamine-based 1,6-diynes | Authors: | Cui, JF Yu, Q O, WY Huang, LW Yang, B Wong, MK |
Issue Date: | 14-May-2023 | Source: | Organic & biomolecular chemistry, 14 May 2022, v. 20, no. 18, p. 3755-3762 | Abstract: | A highly regio- and chemoselective synthesis of 1H-isoindoliums through a facile and novel cascade cyclization reaction of propargylamine-based 1,6-diynes under mild conditions has been developed. Different functional groups were compatible under the optimized reaction conditions, giving the corresponding products in up to 94% yields. Upon treatment with a base, the alkyne moiety of 1H-isoindoliums could be further transformed to allenes in excellent yields. | Publisher: | Royal Society of Chemistry | Journal: | Organic & biomolecular chemistry | ISSN: | 1477-0520 | EISSN: | 1477-0539 | DOI: | 10.1039/d2ob00316c | Rights: | This journal is © The Royal Society of Chemistry 2022 The following publication Cui, J.-F., Yu, Q., O, W.-Y., Huang, L.-W., Yang, B., & Wong, M.-K. (2022). Synthesis of 1H-isoindoliums by electrophile-mediated cascade cyclization/iodination of propargylamine-based 1,6-diynes [10.1039/D2OB00316C]. Organic & Biomolecular Chemistry, 20(18), 3755-3762 is available at https://dx.doi.org/10.1039/d2ob00316c. |
Appears in Collections: | Journal/Magazine Article |
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Cui_1H-Isoindoliums_Electrophile-Mediated_Cascade.pdf | Pre-Published version | 1.22 MB | Adobe PDF | View/Open |
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