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http://hdl.handle.net/10397/95774
Title: | A universal biocompatible coating for enhanced lubrication and bacterial inhibition | Authors: | Suo, D Rao, J Wang, H Zhang, Z Leung, PHM Zhang, H Tao, X Zhao, X |
Issue Date: | 7-Jul-2022 | Source: | Biomaterials science, 7 July 2022, v. 10, no. 13, p. 3493-3502 | Abstract: | Antibacterial coatings that inhibit bacterial adhesion are essential for many implanted medical devices. A variety of antibacterial strategies, such as repelling or killing bacteria, have been developed, but not yet been completely successful. Here, we develop a universal biocompatible coating for enhanced lubrication and bacterial inhibition. The coating is designed based on mussel-inspired surface-attachable dopamine bases and consists of lubricating zwitterionic polymers poly(2-methacryloxyethyl phosphorylcholine) (MPC) and a bacterial membrane destroying anti-bacteria molecule poly(3-hydroxybutyric acid) (PHB). The coating boasts strong adhesion to surfaces of various materials (such as polydimethylsiloxane (PDMS)/ceramic/316L stainless steel (316L SS); it is biocompatible, and cell/platelet/bacteria repelling, significantly inhibiting bacterial growth. We envision that our strategy represents a universal strategy for surface functionalization of a variety of biomedical devices and implants. | Publisher: | Royal Society of Chemistry | Journal: | Biomaterials science | ISSN: | 2047-4830 | EISSN: | 2047-4849 | DOI: | 10.1039/d2bm00598k | Rights: | This journal is © The Royal Society of Chemistry 2022 The following publication Suo, D., et al. (2022). "A universal biocompatible coating for enhanced lubrication and bacterial inhibition." Biomaterials Science 10(13): 3493-3502. is available at https://dx.doi.org/10.1039/D2BM00598K. |
Appears in Collections: | Journal/Magazine Article |
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Suo_Universal_Biocompatible_Coating.pdf | Pre-Published version | 1.69 MB | Adobe PDF | View/Open |
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