Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95773
Title: | Hybrid theranostic microbubbles for ultrasound/photoacoustic imaging guided starvation/low-temperature photothermal/hypoxia-activated synergistic cancer therapy | Authors: | Tian, F Zhong, X Zhao, JK Gu, Y Fan, Y Shi, F Zhang, Y Tan, Y Chen, W Yi, C Yang, M |
Issue Date: | 7-Dec-2021 | Source: | Journal of materials chemistry B, 7 Dec. 2021, v. 9, no. 45, p. 9358-9369 | Abstract: | Constructing a theranostic agent for high-contrast multimodality imaging-guided synergistic therapy with long-term tumor retention and minimum systemic side effects still remains a major challenge. Herein, a hybrid microbubble-based theranostic platform was developed for dual-modality ultrasound (US) and enhanced photoacoustic (PA) imaging-guided synergistic tumor therapy by combining starvation therapy, low-temperature photothermal therapy (PTT), and hypoxia-activated therapy, based on polydopamine (PDA) doped poly(vinyl alcohol) microbubbles loaded with glucose oxidase (GOx) (PDA-PVAMBs@GOx) and hypoxia-activated prodrug (HAP) tirapazamine (TPZ). For dual-modality US/enhanced PA imaging, PDA-PVAMBs provided 6.5-fold amplified PA signals relative to freely dispersed PDA nanoparticles (PDA NPs). For synergistic cancer therapy, oxygen (O2) carried by PDA-PVAMBs@GOx was first released to promote starvation therapy by loaded GOx. Then, moderate near-infrared (NIR) laser irradiation triggered PTT and improved enzymatic activity of GOx with its optimal activity around 47 °C. Subsequently, GOx-mediated tumor starvation depleted O2and exacerbated the hypoxia environment, thereby activating the toxicity of TPZ in the tumor site. Through dual-modality US/PA imaging monitoring, PDA-PVAMBs@GOx with long-term retention (∼7 days) combined with PTT and TPZ significantly inhibited the growth of solid tumors with minimum systemic side effects, which might be a powerful tool for effective tumor treatment. | Publisher: | Royal Society of Chemistry | Journal: | Journal of materials chemistry B | ISSN: | 2050-750X | EISSN: | 2050-7518 | DOI: | 10.1039/d1tb01735g | Rights: | This journal is © The Royal Society of Chemistry 2021 |
Appears in Collections: | Journal/Magazine Article |
Show full item record
Page views
69
Last Week
1
1
Last month
Citations as of May 19, 2024
SCOPUSTM
Citations
10
Citations as of May 16, 2024
WEB OF SCIENCETM
Citations
8
Citations as of May 16, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.