Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/95737
Title: | A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy | Authors: | Xu, Z Jiang, Y Shen, Y Tang, L Hu, Z Lin, G Law, WC Ma, M Dong, B Yong, KT Xu, G Tao, Y Chen, R Yang, C |
Issue Date: | 1-Apr-2022 | Source: | Materials horizons, 1 Apr. 2022, v. 9, no. 4, p. 1283-1292 | Abstract: | Photodynamic efficiency is strongly dependent on the generation rate of reactive oxygen species (ROS) and the tissue penetration depth. Recent advances in materials science reveal that organic molecules with room-temperature phosphorescence (RTP) can potentially serve as efficient photosensitizers owing to their limited dark cytotoxicity and abundant triplet excitons upon light irradiation. In this study, we combine RTP materials with two-photon excitation to improve the ROS generation, therapeutic precision, and tissue penetration of photodynamic therapy. We successfully prepared a novel RTP-based photosensitizer (BF2DCz) with a high photoluminescence quantum yield of 47.7 ± 3% and a remarkable intersystem crossing efficiency of ∼90.3%. By encapsulation into the bovine serum albumin (BSA) matrix, BF2DCz-BSA exhibits excellent biocompatibility, negligible dark toxicity, and superior photostability. Excitation using a femtosecond laser causes BF2DCz-BSA to efficiently generate ROS and precisely exert cell damage at the desired location. | Publisher: | Royal Society of Chemistry | Journal: | Materials horizons | ISSN: | 2051-6347 | EISSN: | 2051-6355 | DOI: | 10.1039/d1mh01869h | Rights: | This journal is © The Royal Society of Chemistry 2022 The following publication Xu, Z., Jiang, Y., Shen, Y., Tang, L., Hu, Z., Lin, G., Law, W.-C., Ma, M., Dong, B., Yong, K.-T., Xu, G., Tao, Y., Chen, R., & Yang, C. (2022). A biocompatible photosensitizer with a high intersystem crossing efficiency for precise two-photon photodynamic therapy [10.1039/D1MH01869H]. Materials Horizons, 9(4), 1283-1292 is available at https://dx.doi.org/10.1039/d1mh01869h. |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Xu_Biocompatible_Photosensitizer_Intersystem.pdf | Pre-Published version | 1.94 MB | Adobe PDF | View/Open |
Page views
81
Last Week
0
0
Last month
Citations as of Sep 22, 2024
Downloads
138
Citations as of Sep 22, 2024
SCOPUSTM
Citations
28
Citations as of Sep 26, 2024
WEB OF SCIENCETM
Citations
28
Citations as of Sep 26, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.