Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94312
Title: | Adipose MDM2 regulates systemic insulin sensitivity | Authors: | Hallenborg, P Jensen, BAH Fjære, E Petersen, RK Belmaâti, MS Rasmussen, SS Gunnarsson, JP Lauritzen, P Cheng, KKY Hermansson, M Sonne, SB Ejsing, CS Xu, A Kratchmarova, I Krüger, M Madsen, L Kristiansen, K Blagoev, B |
Issue Date: | 2021 | Source: | Scientific reports, 2021, v. 11, 21839 | Abstract: | The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in their adipose stores suffer from overt obesity, glucose intolerance, and hepatic steatosis. These mice had decreased levels of circulating palmitoleic acid [non-esterified fatty acid (NEFA) 16:1] concomitant with impaired visceral adipose tissue expression of Scd1 and Ffar4. A similar decrease in Scd and Ffar4 expression was found in in vitro differentiated adipocytes with perturbed MDM2 expression. Lowered MDM2 levels led to nuclear exclusion of the transcriptional cofactors, MORC2 and LIPIN1, and thereby possibly hampered adipocyte function by antagonizing LIPIN1-mediated PPARγ coactivation. Collectively, these data argue for a hitherto unknown interplay between MDM2 and MORC2/LIPIN1 involved in balancing adipocyte function. | Publisher: | Nature Publishing Group | Journal: | Scientific reports | EISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-01240-3 | Rights: | © The Author(s) 2021 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The following publication Hallenborg, P., Jensen, B. A. H., Fjære, E., Petersen, R. K., Belmaâti, M. S., Rasmussen, S. S., ... & Blagoev, B. (2021). Adipose MDM2 regulates systemic insulin sensitivity. Scientific reports, 11, 21839 is available at https://doi.org/10.1038/s41598-021-01240-3 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Hallenborg_Adipose_Regulates_Systemic.pdf | 10.1 MB | Adobe PDF | View/Open |
Page views
55
Last Week
1
1
Last month
Citations as of May 5, 2024
Downloads
21
Citations as of May 5, 2024
SCOPUSTM
Citations
6
Citations as of Apr 4, 2024
WEB OF SCIENCETM
Citations
6
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.