Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/94061
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Biology and Chemical Technology | en_US |
dc.creator | Kong, J | en_US |
dc.creator | Zou, R | en_US |
dc.creator | Law, GL | en_US |
dc.creator | Wang, Y | en_US |
dc.date.accessioned | 2022-08-11T01:06:48Z | - |
dc.date.available | 2022-08-11T01:06:48Z | - |
dc.identifier.issn | 2375-2548 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/94061 | - |
dc.language.iso | en | en_US |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.rights | Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC) (https://creativecommons.org/licenses/by-nc/4.0/). | en_US |
dc.rights | The following publication Kong, J., Zou, R., Law, G.-L., & Wang, Y. (2022). Biomimetic multifunctional persistent luminescence nanoprobes for long-term near-infrared imaging and therapy of cerebral and cerebellar gliomas. Science Advances, 8(10), eabm7077 is available at https://dx.doi.org/10.1126/sciadv.abm7077. | en_US |
dc.title | Biomimetic multifunctional persistent luminescence nanoprobes for long-term near-infrared imaging and therapy of cerebral and cerebellar gliomas | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.doi | 10.1126/sciadv.abm7077 | en_US |
dcterms.abstract | Glioma is the most common malignant primary brain tumor, and the accurate diagnosis of glioma has always been a challenge. Moreover, cerebellar glioma, which is difficult to be detected by magnetic resonance imaging, is not usually diagnosed until after the appearance of clinical symptoms. In this study, TRZD, a near-infrared (NIR) persistent luminescence (PL) nanoparticle with a dual function of imaging and therapy, was synthesized based on ZnGa2O4:Cr3+,Sn4+. TRZD showed excellent rechargeable NIR PL for more than 30 hours in vivo with good tissue penetration for long-term autofluorescence-free imaging. The tumor growth of both the subcutaneous and orthotropic glioma models was significantly inhibited by TRZD. This is the first-time approach using NIR PL nanoprobes for both diagnosis and therapy of glioma. This is also the first-time report of nanotechnology-based diagnosis and therapy of cerebellar gliomas. This study offers a highly promising multifunctional nanoparticle for theranostics of a wide range of brain diseases. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Science advances, 2022, v. 8, no. 10, eabm7077 | en_US |
dcterms.isPartOf | Science advances | en_US |
dcterms.issued | 2022 | - |
dc.identifier.scopus | 2-s2.0-85126078234 | - |
dc.identifier.pmid | 35263137 | - |
dc.identifier.artn | eabm7077 | en_US |
dc.description.validate | 202208 bcrc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | a1548 | - |
dc.identifier.SubFormID | 45390 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.pubStatus | Published | en_US |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
sciadv.abm7077.pdf | 9.25 MB | Adobe PDF | View/Open |
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