Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/93675
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Li, GHY | en_US |
dc.creator | Lam, SKK | en_US |
dc.creator | Wong, ICK | en_US |
dc.creator | Chu, JKP | en_US |
dc.creator | Cheung, CL | en_US |
dc.date.accessioned | 2022-07-25T02:42:34Z | - |
dc.date.available | 2022-07-25T02:42:34Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/93675 | - |
dc.language.iso | en | en_US |
dc.publisher | Molecular Diversity Preservation International (MDPI) | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | en_US |
dc.rights | The following publication Li, G. H. Y., Lam, S. K. K., Wong, I. C. K., Chu, J. K. P., & Cheung, C. L. (2021). Education attainment, intelligence and Covid-19: a Mendelian randomization study. Journal of clinical medicine, 10(21), 4870 is available at https://doi.org/10.3390/jcm10214870 | en_US |
dc.subject | Education | en_US |
dc.subject | Intelligence | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Mendelian randomization | en_US |
dc.title | Education attainment, intelligence and COVID-19 : a mendelian randomization study | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 10 | en_US |
dc.identifier.issue | 21 | en_US |
dc.identifier.doi | 10.3390/jcm10214870 | en_US |
dcterms.abstract | Background: Evidence of socioeconomic inequality in COVID-19-related outcomes is emerging, with a higher risk of infection and mortality observed among individuals with lower education attainment. We aimed to evaluate the potential interventions against COVID-19 from the socioeconomic perspective, including improvement in education and intelligence. | en_US |
dcterms.abstract | Methods: With a two-sample Mendelian randomization approach using summary statistics from the largest genome-wide association meta-analysis, univariable analysis was adopted to evaluate the total causal effects of genetically determined education attainment and intelligence on COVID-19 outcomes. Multivariable analysis was performed to dissect the potential mechanisms. | en_US |
dcterms.abstract | Results: Genetic predisposition to higher education attainment by 1 SD (4.2 years) was independently associated with reduced risk of COVID- 19 severity (OR = 0.508 [95% CI: 0.417–0.617]; p < 0.001). Genetically higher education attainment also lowered the risk of COVID-19 hospitalization (0.685 [0.593–0.791]; p < 0.001), but the association was attenuated after adjustment for beta estimates of intelligence in multivariable analysis. Genetically higher intelligence was associated with reduced risk of COVID-19 hospitalization (0.780 [0.655–0.930]; p = 0.006), with attenuation of association after adjustment for education attainment. Null association was observed for genetically determined education attainment and intelligence with SARS-CoV-2 infection. | en_US |
dcterms.abstract | Conclusion: Education may act independently and jointly with intelligence in improving the COVID-19 outcomes. Improving education may potentially alleviate the COVID-19-related health inequality. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Journal of clinical medicine, Nov. 2021, v. 10, no. 21, 4870 | en_US |
dcterms.isPartOf | Journal of clinical medicine | en_US |
dcterms.issued | 2021-11 | - |
dc.identifier.isi | WOS:000726475800001 | - |
dc.identifier.scopus | 2-s2.0-85117468002 | - |
dc.identifier.pmid | 34768390 | - |
dc.identifier.eissn | 2077-0383 | en_US |
dc.identifier.artn | 4870 | en_US |
dc.description.validate | 202207 bcvc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | HTI-0164 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 60438427 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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jcm-10-04870.pdf | 2.12 MB | Adobe PDF | View/Open |
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