Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/93673
DC Field | Value | Language |
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dc.contributor | Department of Health Technology and Informatics | en_US |
dc.creator | Hsieh, YT | en_US |
dc.creator | Tu, HF | en_US |
dc.creator | Yang, MH | en_US |
dc.creator | Chen, YF | en_US |
dc.creator | Lan, XY | en_US |
dc.creator | Huang, CL | en_US |
dc.creator | Chen, HM | en_US |
dc.creator | Li, WC | en_US |
dc.date.accessioned | 2022-07-25T02:42:18Z | - |
dc.date.available | 2022-07-25T02:42:18Z | - |
dc.identifier.issn | 2041-4889 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/93673 | - |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | © The Author(s) 2021 | en_US |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/. | en_US |
dc.rights | The following publication Hsieh, YT., Tu, HF., Yang, MH. et al. Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors. Cell Death Dis 12, 961 (2021) is available at ttps://doi.org/10.1038/s41419-021-04255-w | en_US |
dc.title | Mitochondrial genome and its regulator TFAM modulates head and neck tumourigenesis through intracellular metabolic reprogramming and activation of oncogenic effectors | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.doi | 10.1038/s41419-021-04255-w | en_US |
dcterms.abstract | Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis is controversial. Current study aims to define TFAM mediated regulations in head and neck cancer (HNC). Multifaceted analyses in HNC cells genetically manipulated for TFAM were performed. Clinical associations of TFAM and mtDNA encoded Electron Transport Chain (ETC) genes in regulating HNC tumourigenesis were also examined in HNC specimens. At cellular level, TFAM silencing led to an enhanced cell growth, motility and chemoresistance whereas enforced TFAM expression significantly reversed these phenotypic changes. These TFAM mediated cellular changes resulted from (1) metabolic reprogramming by directing metabolism towards aerobic glycolysis, based on the detection of less respiratory capacity in accompany with greater lactate production; and/or (2) enhanced ERK1/2-Akt-mTORC-S6 signalling activity in response to TFAM induced mtDNA perturbance. Clinical impacts of TFAM and mtDNA were further defined in carcinogen-induced mouse tongue cancer and clinical human HNC tissues; as the results showed that TFAM and mtDNA expression were significantly dropped in tumour compared with their normal counterparts and negatively correlated with disease progression. Collectively, our data uncovered a tumour-suppressing role of TFAM and mtDNA in determining HNC oncogenicity and potentially paved the way for development of TFAM/mtDNA based scheme for HNC diagnosis. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Cell death & disease, 2021, v. 12, 961 | en_US |
dcterms.isPartOf | Cell death & disease | en_US |
dcterms.issued | 2021 | - |
dc.identifier.isi | WOS:000708496600005 | - |
dc.identifier.scopus | 2-s2.0-85117483958 | - |
dc.identifier.pmid | 34663785 | - |
dc.identifier.artn | 961 | en_US |
dc.description.validate | 202207 bcvc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | HTI-0165 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Most-106-2314-B-010-005-MY3, Most-109-2628-B-010-008-, Most-110-2628-B-A49A-511- and Most-110-2314-B-A49A- 516-MY3 from Ministry of Science and Technology, Taiwan | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 59393541 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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s41419-021-04255-w.pdf | 7.81 MB | Adobe PDF | View/Open |
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