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Title: | The effect of different measurement modalities in the association of lean mass with mortality : a systematic review and meta-analysis | Authors: | Li, GHY Lee, GKY Au, PCM Chan, M Li, HL Cheung, BMY Wong, ICK Lee, VHF Mok, J Yip, BHK Cheng, KKY Wu, CH Cheung, CL |
Issue Date: | Mar-2021 | Source: | Osteoporosis and sarcopenia, Mar. 2021, v. 7, suppl. 1, p. S13-S18 | Abstract: | Objectives: Lean mass is commonly measured by 3 modalities, dual energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and computerized tomography (CT). CT is considered the most accurate, while lean mass measured by DXA and BIA often consists of non-muscle compartment, and hence considered less accurate when compared with CT. It remains unclear if the association of lean mass with mortality would differ using different measurement modalities. Methods: A systematic review and meta-analysis of lean mass and mortality was conducted. The analysis was stratified by different measurement modalities and health conditions. Pooled hazard ratios were estimated using a random effects model. Results: This meta-analysis included 188 studies with 98 468 participants. Reduced lean mass measured by BIA, DXA, and CT, was associated with increased risk of mortality with a hazard ratio (HR) of 1.35 (95% CI, 1.21–1.49), 1.18 (95% CI, 1.06–1.30), and 1.44 (95% CI, 1.32–1.57), respectively. Similarly, low lean mass defined by BIA-, DXA-, and CT-measurement was associated with increased risk of mortality, with an HR of 1.81 (95% CI, 1.56–2.10), 1.44 (95% CI, 1.29–1.60), and 1.78 (95% CI, 1.64–1.93). Conclusions: Reduced and low lean mass were robustly associated with increased mortality in studies using different measurement modalities. |
Keywords: | DXA BIA CT Mortality Lean mass |
Publisher: | Elsevier B.V | Journal: | Osteoporosis and sarcopenia | ISSN: | 2405-5255 | EISSN: | 2405-5263 | DOI: | 10.1016/j.afos.2021.02.004 | Rights: | © 2021 The Korean Society of Osteoporosis. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). The following publication Li, G. H. Y., Lee, G. K. Y., Au, P. C. M., Chan, M., Li, H. L., Cheung, B. M. Y., ... & Cheung, C. L. (2021). The effect of different measurement modalities in the association of lean mass with mortality: A systematic review and meta-analysis. Osteoporosis and sarcopenia, 7, S13-S18 is available at https://doi.org/10.1016/j.afos.2021.02.004 |
Appears in Collections: | Journal/Magazine Article |
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