Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/93328
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Applied Mathematics | en_US |
dc.creator | Jiang, B | en_US |
dc.creator | Song, R | en_US |
dc.creator | Li, J | en_US |
dc.creator | Zeng, D | en_US |
dc.date.accessioned | 2022-06-15T03:42:44Z | - |
dc.date.available | 2022-06-15T03:42:44Z | - |
dc.identifier.issn | 1017-0405 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/93328 | - |
dc.language.iso | en | en_US |
dc.publisher | Academia Sinica, Institute of Statistical Science | en_US |
dc.rights | Posted with permission of the publisher. | en_US |
dc.subject | Dynamic treatment regime | en_US |
dc.subject | Entropy learning | en_US |
dc.subject | Personalized medicine | en_US |
dc.title | Entropy learning for dynamic treatment regimes | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 1633 | en_US |
dc.identifier.epage | 1710 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.doi | 10.5705/ss.202018.0076 | en_US |
dcterms.abstract | Estimating optimal individualized treatment rules (ITRs) in single or multi-stage clinical trials is one key solution to personalized medicine and has received more and more attention in statistical community. Recent development suggests that using machine learning approaches can significantly improve the estimation over model-based methods. However, proper inference for the estimated ITRs has not been well established in machine learning based approaches. In this paper, we propose a entropy learning approach to estimate the optimal individualized treatment rules (ITRs). We obtain the asymptotic distributions for the estimated rules so further provide valid inference. The proposed approach is demonstrated to perform well in finite sample through extensive simulation studies. Finally, we analyze data from a multi-stage clinical trial for depression patients. Our results offer novel findings that are otherwise not revealed with existing approaches. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Statistica sinica, 2019, v. 29, no. 4, p. 1633-1710 | en_US |
dcterms.isPartOf | Statistica sinica | en_US |
dcterms.issued | 2019 | - |
dc.description.validate | 202206 bcfc | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | AMA-0257 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 23634004 | - |
Appears in Collections: | Journal/Magazine Article |
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File | Description | Size | Format | |
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A29N41-9.pdf | 943.25 kB | Adobe PDF | View/Open |
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