Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/93249
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Zhang, JJQ | en_US |
dc.creator | Fong, KNK | en_US |
dc.creator | Ouyang, RG | en_US |
dc.creator | Siu, AMH | en_US |
dc.creator | Kranz, GS | en_US |
dc.date.accessioned | 2022-06-10T07:02:13Z | - |
dc.date.available | 2022-06-10T07:02:13Z | - |
dc.identifier.issn | 0965-2140 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/93249 | - |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | © 2019 Society for the Study of Addiction | en_US |
dc.rights | This is the peer reviewed version of the following article: Zhang, J. J. Q., Fong, K. N. K., Ouyang, R., Siu, A. M. H., and Kranz, G. S. (2019) Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence: a systematic review and meta-analysis. Addiction, 114: 2137– 2149, which has been published in final form at https://doi.org/10.1111/add.14753. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | en_US |
dc.subject | Addiction | en_US |
dc.subject | Craving | en_US |
dc.subject | Meta-analysis | en_US |
dc.subject | Substance dependence | en_US |
dc.subject | Systematic review | en_US |
dc.subject | Transcranial magnetic stimulation | en_US |
dc.title | Effects of repetitive transcranial magnetic stimulation (rTMS) on craving and substance consumption in patients with substance dependence : a systematic review and meta-analysis | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 2137 | en_US |
dc.identifier.epage | 2149 | en_US |
dc.identifier.volume | 114 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.doi | 10.1111/add.14753 | en_US |
dcterms.abstract | Background and Aims: Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as an intervention for treating substance dependence. We aimed to assess evidence of the anti-craving and consumption-reducing effects of rTMS in patients with alcohol, nicotine and illicit drug dependence. | en_US |
dcterms.abstract | Methods: A systematic review and meta-analysis of 26 randomized controlled trials (RCTs) published from January 2000 to October 2018 that investigated the effects of rTMS on craving and substance consumption in patients with nicotine, alcohol and illicit drug dependence (n = 748). Craving, measured using self-reported questionnaires or visual analog scale, and substance consumption, measured using self-report substance intake or number of addiction relapse cases, were considered as primary and secondary outcomes, respectively. Substance type, study design and rTMS parameters were used as the independent factors in the meta-regression. | en_US |
dcterms.abstract | Results: Results showed that excitatory rTMS of the left dorsolateral pre-frontal cortex (DLPFC) significantly reduced craving [Hedges' g = −0.62; 95% confidence interval (CI) = −0.89 to −0.35; P < 0.0001], compared with sham stimulation. Moreover, meta-regression revealed a significant positive association between the total number of stimulation pulses and effect size among studies using excitatory left DLPFC stimulation (P = 0.01). Effects of other rTMS protocols on craving were not significant. However, when examining substance consumption, excitatory rTMS of the left DLPFC and excitatory deep TMS (dTMS) of the bilateral DLPFC and insula revealed significant consumption-reducing effects, compared with sham stimulation. | en_US |
dcterms.abstract | Conclusion: Excitatory repetitive transcranial magnetic stimulation of the dorsolateral pre-frontal cortex appears to have an acute effect on reducing craving and substance consumption in patients with substance dependence. The anti-craving effect may be associated with stimulation dose. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Addiction, Dec. 2019, v. 114, no. 12, p. 2137-2149 | en_US |
dcterms.isPartOf | Addiction | en_US |
dcterms.issued | 2019-12 | - |
dc.identifier.scopus | 2-s2.0-85070793486 | - |
dc.identifier.pmid | 31328353 | - |
dc.identifier.eissn | 1360-0443 | en_US |
dc.description.validate | 202206 bcch | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | RS-0161 | - |
dc.description.fundingSource | Self-funded | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 14299466 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Zhang_Effects_Repetitive_Transcranial.pdf | Pre-Published version | 1.08 MB | Adobe PDF | View/Open |
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