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Title: | The neurobiology of prefrontal transcranial direct current stimulation (tDCS) in promoting brain plasticity : a systematic review and meta-analyses of human and rodent studies | Authors: | Chan, MMY Yau, SSY Han, YMY |
Issue Date: | Jun-2021 | Source: | Neuroscience and biobehavioral reviews, June 2021, v. 125, p. 392-416 | Abstract: | The neurobiological mechanisms underlying prefrontal transcranial direct current stimulation (tDCS) remain elusive. Randomized, sham-controlled trials in humans and rodents applying in vivo prefrontal tDCS were included to explore whether prefrontal tDCS modulates resting-state and event-related functional connectivity, neural oscillation and synaptic plasticity. Fifty studies were included in the systematic review and 32 in the meta-analyses. Neuroimaging meta-analysis indicated anodal prefrontal tDCS significantly enhanced bilateral median cingulate activity [familywise error (FWE)-corrected p <.005]; meta-regression revealed a positive relationship between changes in median cingulate activity after tDCS and current density (FWE-corrected p <.005) as well as electric current strength (FWE-corrected p <.05). Meta-analyses of electroencephalography and magnetoencephalography data revealed nonsignificant changes (ps >.1) in both resting-state and event-related oscillatory power across all frequency bands. Applying anodal tDCS over the rodent hippocampus/prefrontal cortex enhanced long-term potentiation and brain-derived neurotrophic factor expression in the stimulated brain regions (ps <.005). Evidence supporting prefrontal tDCS administration is preliminary; more methodologically consistent studies evaluating its effects on cognitive function that include brain activity measurements are needed. | Keywords: | BDNF EEG fMRI Functional connectivity Human LTP MEG Meta-analysis Neurobiology Oscillation Rodent tDCS |
Journal: | Neuroscience & biobehavioral reviews | ISSN: | 0149-7634 | DOI: | 10.1016/j.neubiorev.2021.02.035 | Rights: | © 2021 Elsevier Ltd. All rights reserved. © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ The following publication Chan, M. M., Yau, S. S., & Han, Y. M. (2021). The neurobiology of prefrontal transcranial direct current stimulation (tDCS) in promoting brain plasticity: A systematic review and meta-analyses of human and rodent studies. Neuroscience & Biobehavioral Reviews, 125, 392-416 is available at https://doi.org/10.1016/j.neubiorev.2021.02.035. |
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