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http://hdl.handle.net/10397/92681
Title: | Mechanistic links between systemic hypertension and open angle glaucoma | Authors: | Cui, YK Pan, L Lam, T Wen, CY Do, CW |
Issue Date: | 2022 | Source: | Clinical and experimental optometry, 2022, v. 105, no. 4, p. 362-371 | Abstract: | Systemic hypertension or hypertension is a very common chronic age-related disease worldwide. It is typically characterised by a sustained elevation of blood pressure, particularly when the systolic blood pressure and/or diastolic blood pressure are of more than 140 mmHg and 90 mmHg, respectively. If hypertension is not well controlled, it may lead to an increased risk of stroke and heart attack. It has been shown that hypertension is linked to various ocular diseases, including cataract, diabetic retinopathy, age-related macular degeneration, and glaucoma. Glaucoma is the leading cause of irreversible blindness worldwide. Primary open angle glaucoma is the most common form of the disease and is usually characterised by an increase in intraocular pressure. This condition, together with normal tension glaucoma, constitutes open angle glaucoma. Systemic hypertension has been identified as a risk factor for open angle glaucoma. It is speculated that blood pressure is involved in the pathogenesis of open angle glaucoma by altering intraocular pressure or ocular blood flow, or both. Recent evidence has shown that both extremely high and low blood pressure are associated with increased risk of open angle glaucoma. Additional pathogenic mechanisms, including increased inflammation likely to be involved in the development and progression of these two diseases, are discussed. | Keywords: | Asystemic hypertension Glaucoma Intraocular pressure Ocular perfusion pressure |
Publisher: | Taylor & Francis | Journal: | Clinical and experimental optometry | ISSN: | 0816-4622 | EISSN: | 1444-0938 | DOI: | 10.1080/08164622.2021.1964332 | Rights: | © 2021 Optometry Australia This is an Accepted Manuscript of an article published by Taylor & Francis in Clinical and Experimental Optometry on 17 Aug 2021 (published online), available at: http://www.tandfonline.com/10.1080/08164622.2021.1964332 |
Appears in Collections: | Journal/Magazine Article |
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Cui_Mechanistic_Links_Between.pdf | Pre-Published version | 411.38 kB | Adobe PDF | View/Open |
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