Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92469
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Biomedical Engineering | en_US |
dc.creator | Xian, Q | en_US |
dc.creator | Qiu, Z | en_US |
dc.creator | Kala, S | en_US |
dc.creator | Wong, KF | en_US |
dc.creator | Guo, J | en_US |
dc.creator | Sun, L | en_US |
dc.date.accessioned | 2022-04-07T06:32:23Z | - |
dc.date.available | 2022-04-07T06:32:23Z | - |
dc.identifier.issn | 0885-3010 | en_US |
dc.identifier.uri | http://hdl.handle.net/10397/92469 | - |
dc.language.iso | en | en_US |
dc.publisher | Institute of Electrical and Electronics Engineers | en_US |
dc.rights | © 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | en_US |
dc.rights | The following publication Q. Xian, Z. Qiu, S. Kala, K. F. Wong, J. Guo and L. Sun, "Behavioral and Functional Assessment of Ultrasound Neuromodulation on Caenorhabditis Elegans," in IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 68, no. 6, pp. 2150-2154, June 2021 is available at https://doi.org/10.1109/TUFFC.2021.3057873. | en_US |
dc.subject | Caenorhabditis elegans | en_US |
dc.subject | Calcium imaging | en_US |
dc.subject | Ultrasound neural stimulation | en_US |
dc.title | Behavioral and functional assessment of ultrasound neuromodulation on caenorhabditis elegans | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.spage | 2150 | en_US |
dc.identifier.epage | 2154 | en_US |
dc.identifier.volume | 68 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.doi | 10.1109/TUFFC.2021.3057873 | en_US |
dcterms.abstract | Ultrasound brain stimulation is a promising modality for probing brain function and treating brain diseases. However, its mechanism is as yet unclear, and in vivo effects are not well-understood. Here, we present a top-down strategy for assessing ultrasound bioeffects in vivo, using Caenorhabditis elegans. Behavioral and functional changes of single worms and of large populations upon ultrasound stimulation were studied. Worms were observed to significantly increase their average speed upon ultrasound stimulation, adapting to it upon continued treatment. Worms also generated more reversal turns when ultrasound was ON, and within a minute post-stimulation, they performed significantly more reversal and omega turns than prior to ultrasound. In addition, in vivo calcium imaging showed that the neural activity in the worms' heads and tails was increased significantly by ultrasound stimulation. In all, we conclude that ultrasound can directly activate the neurons of worms in vivo, in both of their major neuronal ganglia, and modify their behavior. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | IEEE transactions on ultrasonics, ferroelectrics, and frequency control, June 2021, v. 68, no. 6, p. 2150-2154 | en_US |
dcterms.isPartOf | IEEE transactions on ultrasonics, ferroelectrics, and frequency control | en_US |
dcterms.issued | 2021-06 | - |
dc.identifier.scopus | 2-s2.0-85101469400 | - |
dc.identifier.pmid | 33556006 | - |
dc.identifier.eissn | 1525-8955 | en_US |
dc.description.validate | 202204 bcfc | en_US |
dc.description.oa | Accepted Manuscript | en_US |
dc.identifier.FolderNumber | RGC-B1-007, BME-0025, a1632 | - |
dc.identifier.SubFormID | 45673 | - |
dc.description.fundingSource | RGC | en_US |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | Others: University Research Facility in Behavioral and Systems Neuroscience (UBSN) of the Hong Kong Polytechnic University; Innovation and Technology Fund | en_US |
dc.description.fundingText | Hong Kong Research Grant Council; Innovation Technology Fund; Science and Technology Planning Project of Guangdong Province | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 49974480 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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Xian_Behavioral_Functional_Assessment.pdf | Pre-Published version | 1.27 MB | Adobe PDF | View/Open |
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