Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92394
DC Field | Value | Language |
---|---|---|
dc.contributor | Department of Rehabilitation Sciences | en_US |
dc.creator | Zhang, H | en_US |
dc.creator | Hui, ES | en_US |
dc.creator | Cao, P | en_US |
dc.creator | Mak, HKF | en_US |
dc.date.accessioned | 2022-03-29T04:25:58Z | - |
dc.date.available | 2022-03-29T04:25:58Z | - |
dc.identifier.uri | http://hdl.handle.net/10397/92394 | - |
dc.language.iso | en | en_US |
dc.publisher | MDPI AG | en_US |
dc.rights | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/). | en_US |
dc.rights | The following publication Zhang, H., Hui, E. S., Cao, P., & Mak, H. K. F. (2021). Relationship between Amyloid-β Deposition and the Coupling between Structural and Functional Brain Networks in Patients with Mild Cognitive Impairment and Alzheimer’s Disease. Brain Sciences, 11(11), 1535 is available at https://doi.org/10.3390/BRAINSCI11111535 | en_US |
dc.subject | 18F-flutemetamol PET-CT | en_US |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | Amyloid-β deposition | en_US |
dc.subject | Coupling between functional and structural networks | en_US |
dc.subject | Resting-state functional magnetic resonance imaging | en_US |
dc.title | Relationship between amyloid-β deposition and the coupling between structural and functional brain networks in patients with mild cognitive impairment and Alzheimer’s disease | en_US |
dc.type | Journal/Magazine Article | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.doi | 10.3390/BRAINSCI11111535 | en_US |
dcterms.abstract | Previous studies have demonstrated that the accumulation of amyloid-β (Aβ) pathologies has distinctive stage-specific effects on the structural and functional brain networks along the Alzheimer’s disease (AD) continuum. A more comprehensive account of both types of brain network may provide a better characterization of the stage-specific effects of Aβ pathologies. A potential candidate for this joint characterization is the coupling between the structural and functional brain networks (SC-FC coupling). We therefore investigated the effect of Aβ accumulation on global SC-FC coupling in patients with mild cognitive impairment (MCI), AD, and healthy controls. Patients with MCI were dichotomized according to their level of Aβ pathology seen in18F-flutemetamol PET-CT scans—namely, Aβ-negative and Aβ-positive. Our results show that there was no difference in global SC-FC coupling between different cohorts. During the prodromal AD stage, there was a significant negative correlation between the level of Aβ pathology and the global SC-FC coupling of MCI patients with positive Aβ, but no significant correlation for MCI patients with negative Aβ. During the AD dementia stage, the correlation between Aβ pathology and global SC-FC coupling in patients with AD was positive. Our results suggest that Aβ pathology has distinctive stage-specific effects on global coupling between the structural and functional brain networks along the AD continuum. | en_US |
dcterms.accessRights | open access | en_US |
dcterms.bibliographicCitation | Brain sciences, Nov. 2021, v. 11, no. 11, 1535 | en_US |
dcterms.isPartOf | Brain sciences | en_US |
dcterms.issued | 2021-11 | - |
dc.identifier.scopus | 2-s2.0-85121676223 | - |
dc.identifier.eissn | 2076-3425 | en_US |
dc.identifier.artn | 1535 | en_US |
dc.description.validate | 202203 bckw | en_US |
dc.description.oa | Version of Record | en_US |
dc.identifier.FolderNumber | RS-0503 | - |
dc.description.fundingSource | Others | en_US |
dc.description.fundingText | State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong | en_US |
dc.description.pubStatus | Published | en_US |
dc.identifier.OPUS | 58219462 | - |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
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brainsci-11-01535-v2.pdf | 13.71 MB | Adobe PDF | View/Open |
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