Please use this identifier to cite or link to this item:
http://hdl.handle.net/10397/92368
Title: | Surface-modified wooden-tip electrospray ionization mass spectrometry for enhanced detection of analytes in complex samples | Authors: | Hu, B So, PK Yang, Y Deng, J Choi, YC Luan, T Yao, ZP |
Issue Date: | 6-Feb-2018 | Source: | Analytical chemistry, 6 Feb. 2018, v. 90, no. 3, p. 1759-1766 | Abstract: | Replacement of capillary with solid substrates for sample loading and ionization has created many new possibilities for electrospray ionization mass spectrometry (ESI-MS). Surface modification is an attractive strategy to enhance the analytical capability of solid-substrate ESI-MS and allow understanding the relationship between surface activity of solid substrates and analytical properties. In this study, we performed surface modification of wooden tips with hydrophobic (C18), basic (NH2), and acidic (SO3H) functional groups and applied various sampling methods, i.e., extractive sampling and direct loading, to comprehensively investigate the analytical properties of solid-substrate ESI-MS. Our results showed that, for the direct loading method, analytes with weak interactions with solid-substrate surface could be readily sprayed out for detection. While for the extractive sampling method, analytes strongly retained on solid-substrate surface could be selectively enriched and detected, and a washing step after sample loading could effectively remove unbound components for reducing interference. Overall, the insights on the effects of surface-analyte interactions on the analytical features obtained in this study could aid the development of surface-modified strategies for enhancing the analytical capability of solid-substrate ESI-MS. | Publisher: | American Chemical Society | Journal: | Analytical chemistry | ISSN: | 0003-2700 | EISSN: | 1520-6882 | DOI: | 10.1021/acs.analchem.7b03675 | Rights: | © 2018 American Chemical Society This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.analchem.7b03675 |
Appears in Collections: | Journal/Magazine Article |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Hu_Surface-Modified_Wooden-Tip_Electrospray.pdf | Pre-Published version | 1.88 MB | Adobe PDF | View/Open |
Page views
59
Last Week
0
0
Last month
Citations as of Apr 28, 2024
Downloads
87
Citations as of Apr 28, 2024
SCOPUSTM
Citations
60
Citations as of Apr 26, 2024
WEB OF SCIENCETM
Citations
58
Citations as of May 2, 2024
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.