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http://hdl.handle.net/10397/90859
Title: | TGF-β1 signaling : immune dynamics of chronic kidney diseases | Authors: | Tang, PCT Chan, ASW Zhang, CB García, Córdoba, CA Zhang, YY To, KF Leung, KT Lan, HY Tang, PMK |
Issue Date: | Feb-2021 | Source: | Frontiers in medicine, Feb. 2021, v. 8, 628519 | Abstract: | Chronic kidney disease (CKD) is a major cause of morbidity and mortality worldwide, imposing a great burden on the healthcare system. Regrettably, effective CKD therapeutic strategies are yet available due to their elusive pathogenic mechanisms. CKD is featured by progressive inflammation and fibrosis associated with immune cell dysfunction, leading to the formation of an inflammatory microenvironment, which ultimately exacerbating renal fibrosis. Transforming growth factor β1 (TGF-β1) is an indispensable immunoregulator promoting CKD progression by controlling the activation, proliferation, and apoptosis of immunocytes via both canonical and non-canonical pathways. More importantly, recent studies have uncovered a new mechanism of TGF-β1 for de novo generation of myofibroblast via macrophage-myofibroblast transition (MMT). This review will update the versatile roles of TGF-β signaling in the dynamics of renal immunity, a better understanding may facilitate the discovery of novel therapeutic strategies against CKD. | Keywords: | Chronic kidney disease Immunity Kidney fibrosis Renal inflammation Transforming growth factor β |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in medicine | EISSN: | 2296-858X | DOI: | 10.3389/fmed.2021.628519 | Rights: | © 2021 Tang, Chan, Zhang, García Córdoba, Zhang, To, Leung, Lan and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Tang PC-T, Chan AS-W, Zhang C-B, García Córdoba CA, Zhang Y-Y, To K-F, Leung K-T, Lan H-Y and Tang PM-K (2021) TGF-β1 Signaling: Immune Dynamics of Chronic Kidney Diseases. Front. Med. 8:628519 is available at https://doi.org/10.3389/fmed.2021.628519 |
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