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Title: | Molecular epidemiology and clone transmission of carbapenem-resistant acinetobacter baumannii in ICU rooms | Authors: | Zhang, X Li, F Awan, F Jiang, H Zeng, Z Lv, W |
Issue Date: | Feb-2021 | Source: | Frontiers in cellular and infection microbiology, Feb. 2021, v. 11, 633817 | Abstract: | Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major cause of nosocomial infections and hospital outbreaks worldwide, remaining a critical clinical concern. Here we characterized and investigated the phylogenetic relationships of 105 CRAB isolates from an intensive care unit from one hospital in China collected over six years. All strains carried blaOXA-23, blaOXA-66 genes for carbapenem resistance, also had high resistance gene, virulence factor, and insertion sequence burdens. Whole-genome sequencing revealed all strains belonged to ST2, the global clone CC2. The phylogenetic analysis based on the core genome showed all isolates were dominated by a single lineage of three clusters and eight different clones. Two clones were popular during the collection time. Using chi-square test to identify the epidemiologically meaningful groupings, we found the significant difference in community structure only existed in strains from separation time. The haplotype and median-joining network analysis revealed genetic differences appeared among clusters and changes occurred overtime in the dominating cluster. Our results highlighted substantial multidrug-resistant CRAB burden in the hospital ICU environment demonstrating potential clone outbreak in the hospital. | Keywords: | Acinetobacter baumannii Carbapenem-resistant Clone spread Nosocomial infection Whole-genome sequencing |
Publisher: | Frontiers Research Foundation | Journal: | Frontiers in cellular and infection microbiology | ISSN: | 2235-2988 | DOI: | 10.3389/fcimb.2021.633817 | Rights: | © 2021 Zhang, Li, Awan, Jiang, Zeng and Lv. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. The following publication Zhang X, Li F, Awan F, Jiang H, Zeng Z and Lv W (2021) Molecular Epidemiology and Clone Transmission of Carbapenem-Resistant Acinetobacter baumannii in ICU Rooms. Front. Cell. Infect. Microbiol. 11:633817 is available at https://doi.org/10.3389/fcimb.2021.633817 |
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