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http://hdl.handle.net/10397/90856
Title: | Dual-targeting peptide-guided approach for precision delivery and cancer monitoring by using a safe upconversion nanoplatform | Authors: | Zha, S Chau, HF Chau, WY Chan, LS Lin, J Lo, KW ChiShing, Cho, W Yip, YL Tsao, SW Farrell, PJ Feng, L Di, JM Law, GL Lung, HL Wong, KL |
Issue Date: | Mar-2021 | Source: | Advanced science, 3 Mar. 2021, v. 8, no. 5, 2002919 | Abstract: | Using Epstein-Barr virus (EBV)-induced cancer cells and HeLa cells as a comparative study model, a novel and safe dual-EBV-oncoproteins-targeting pH-responsive peptide engineering, coating, and guiding approach to achieve precision targeting and treatment strategy against EBV-associated cancers is introduced. Individual functional peptide sequences that specifically bind to two overexpressed EBV-specific oncoproteins, EBNA1 (a latent cellular protein) and LMP1 (a transmembrane protein), are engineered in three different ways and incorporated with a pH-sensitive tumor microenvironment (TME)-cleavable linker onto the upconversion nanoparticles (UCNP) NaGdF4:Yb3+, Er3+@NaGdF4 (UCNP-Pn, n = 5, 6, and 7). A synergistic combination of the transmembrane LMP1 targeting ability and the pH responsiveness of UCNP-Pn is found to give specific cancer differentiation with higher cellular uptake and accumulation in EBV-infected cells, thus a lower dose is needed and the side effects and health risks from treatment would be greatly reduced. It also gives responsive UC signal enhancement upon targeted dual-protein binding and shows efficacious EBV cancer inhibition in vitro and in vivo. This is the first example of simultaneous imaging and inhibition of two EBV latent proteins, and serves as a blueprint for next-generation peptide-guided precision delivery nanosystem for the safe monitoring and treatment against one specific cancer. | Keywords: | EBV-associated cancer imaging Lanthanide upconversion nanoplatform Peptide-guided precision cancer therapy PH-responsive peptide Selective EBV-infected cytotoxicity |
Publisher: | Wiley-VCH | Journal: | Advanced science | ISSN: | 2198-3844 | DOI: | 10.1002/advs.202002919 | Rights: | © 2021 The Authors. Advanced Science published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The following publication Zha, S., Chau, H. F., Chau, W. Y., Chan, L. S., Lin, J., Lo, K. W., ... & Wong, K. L. (2021). Dual‐Targeting Peptide‐Guided Approach for Precision Delivery and Cancer Monitoring by Using a Safe Upconversion Nanoplatform. Advanced Science, 8(5), 2002919 is available at https://doi.org/10.1002/advs.202002919 |
Appears in Collections: | Journal/Magazine Article |
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